Inspiratory Muscle Training in Multiple Sclerosis

Effects of a 12-week Inspiratory Muscle Training Program With Low Resistance in Patients With Multiple Sclerosis

Status unknownNot a drug-phase studyMS (type not specified)NCT03887546

What it found

No results found

We found no results in the registry or in papers.

What was tested

Treatment tested

  • Inspiratory muscle trainer

Compared with

  • Respiratory exercise

What it measured

Main measures

  • Maximal inspiratory pressure (MIP)

    5 minutes

    Physical function

  • Maximal expiratory pressure (MEP)

    5 minutes

    Nerve conduction tests

Other measures (8)

  • Dyspnea

    1 minute

    Fatigue

  • Maximum voluntary ventilation (MVV)

    1 minute

  • Forced expiratory volume in the first second (FEV1)

    1 minute

  • Peak expiratory flow (PEF)

    1 minute

  • Mean expiratory flow (FEF25-75)

    1 minute

  • Vital capacity (VC)

    1 minute

  • Tidal volume (VT)

    1 minute

  • Forced vital capacity (FVC)

    1 minute

Who could take part

MS (type not specified) · 18 and over

Show the full criteria

Inclusion criteria

* Diagnosed with MS * Over 18 years old * Disability lower than 9 in the EDSS * Be able to understand the objectives of the study

Exclusion criteria

* Participants with a current or past neurological pathology other than MS * Relapse of MS or any respiratory pathology during the 4 weeks prior to the start of the study * Any other complication that may impede the performance of the evaluation tests or breathing techniques

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

Objective: To evaluate the effectiveness of a low-intensity protocol of inspiratory muscle training (IMT) to improve respiratory strength, spirometric parameters and dyspnea in patients with multiple sclerosis (MS). Design: Clinical trial. Randomized. Participants: 67 patients with MS, distributed in two groups, intervention and control. Intervention: Intervention group train using IMT for 12 weeks, 5 days/week, 15 minutes/day (20% maximum inspiratory pressure (MIP) during the first two weeks and 30% MIP after the second week). Control group follow a respiratory exercise program involving nasal breathing and maximum exhalation during 12 weeks, 5 days/week, 15 minutes/day. Evaluations: Determination of the MIP and the maximum expiratory pressure (MEP); spirometry - maximum voluntary ventilation (MVV), peak expiratory flow (PEF), tidal volume (TV); dyspnea using the Borg scale and clinical evaluations.

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History

    1. Started

      Apr 2019

    2. Main results due

      Jul 2019

    3. Finished

      Sept 2019

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