Sit Less or Exercise More: Impact on Cardiometabolic Health in MS

Sit Less or Exercise More: Impact on Cardiometabolic Health in Multiple Sclerosis

CompletedNot a drug-phase studyMS (type not specified)NCT03919058

What it found

Paper found, not read

A paper reports the results; we have not read it yet. See Papers below.

What was tested

Treatment tested

  • Increased sitting time (sit regime)
  • Non-exercise physical activity (sit less regime)
  • Structured exercise (exercise regime)

Compared with

  • Baseline activity (control regime)

What it measured

Main measures

  • Steps per day

    Day 1 to 4 of the control regime

    Physical function

  • Sitting time

    Day 1 to 4 of the control regime

    Physical function

  • Standing time

    Day 1 to 4 of the control regime

    Physical function

  • Stepping time

    Day 1 to 4 of the control regime

    Physical function

  • Concentration of glucose

    Day after the control regime

  • Concentration of insulin

    Day after the control regime

  • Concentration of total cholesterol

    Day after the control regime

  • Concentration of high density lipoprotein cholesterol (HDL-cholesterol)

    Day after the control regime

  • Concentration of low density lipoprotein cholesterol (LDL-cholesterol)

    Day after the control regime

  • Concentration of non-high densitiy lipoprotein cholesterol (non-HDL cholesterol)

    Day after the control regime

  • Concentration of triglyceride

    Day after the control regime

  • Concentration of apolipoprotein A1 (apo A1)

    Day after the control regime

  • Concentration of apolipoprotein B (apo B)

    Day after the control regime

  • Concentration of free fatty acids (FFA)

    Day after the control regime

  • Concentration of C-reactive protein (CRP)

    Day after the control regime

  • Concentration of interleukin 1 (IL-1)

    Day after the control regime

    Immune response

  • Concentration of interleukin 6 (IL-6)

    Day after the control regime

    Immune response

  • Steps per day

    Day 1 to 4 of the Sit regime

    Physical function

  • Sitting time

    Dag 1 to 4 of the Sit regime

    Physical function

  • Standing time

    Day 1 to 4 of the Sit regime

    Physical function

  • Stepping time

    Day 1 to 4 of the Sit regime

    Physical function

  • Concentration of glucose

    Day after the Sit regime

  • Concentration of insulin

    Day after the Sit regime

  • Concentration of total cholesterol

    Day after the Sit regime

  • Concentration of high density lipoprotein cholesterol (HDL-cholesterol)

    Day after the Sit regime

  • Concentration of low density lipoprotein cholesterol (LDL-cholesterol)

    Day after the Sit regime

  • Concentration of non-high densitiy lipoprotein cholesterol (non-HDL cholesterol)

    Day after the Sit regime

  • Concentration of triglyceride

    Day after the Sit regime

  • Concentration of apolipoprotein A1 (apo A1)

    Day after the Sit regime

  • Concentration of apolipoprotein B (apo B)

    Day after the Sit regime

  • Concentration of free fatty acids (FFA)

    Day after the Sit regime

  • Concentration of C-reactive protein (CRP)

    Day after the Sit regime

  • Concentration of interleukin 1 (IL-1)

    Day after the Sit regime

    Immune response

  • Concentration of interleukin 6 (IL-6)

    Day after the Sit regime

    Immune response

  • Steps per day

    Day 1 to 4 of the Sit Less regime

    Physical function

  • Sitting time

    Day 1 to 4 of the Sit Less regime

    Physical function

  • Standing time

    Day 1 to 4 of the Sit Less regime

    Physical function

  • Stepping time

    Day 1 to 4 of the Sit Less regime

    Physical function

  • Concentration of glucose

    Day after the Sit Less regime

  • Concentration of insulin

    Day after the Sit Less regime

  • Concentration of total cholesterol

    Day after the Sit Less regime

  • Concentration of high density lipoprotein cholesterol (HDL-cholesterol)

    Day after the Sit Less regime

  • Concentration of low density lipoprotein cholesterol (LDL-cholesterol)

    Day after the Sit Less regime

  • Concentration of non-high densitiy lipoprotein cholesterol (non-HDL cholesterol)

    Day after the Sit Less regime

  • Concentration of triglyceride

    Day after the Sit Less regime

  • Concentration of apolipoprotein A1 (apo A1)

    Day after the Sit Less regime

  • Concentration of apolipoprotein B (apo B)

    Day after the Sit Less regime

  • Concentration of free fatty acids (FFA)

    Day after the Sit Less regime

  • Concentration of C-reactive protein (CRP)

    Day after the Sit Less regime

  • Concentration of interleukin 1 (IL-1)

    Day after the Sit Less regime

    Immune response

  • Concentration of interleukin 6 (IL-6)

    Day after the Sit Less regime

    Immune response

  • Steps per day

    Day 1 to 4 of the Exercise regime

    Physical function

  • Sitting time

    Day 1 to 4 of the Exercise regime

    Physical function

  • Standing time

    Day 1 to 4 of the Exercise regime

    Physical function

  • Stepping time

    Day 1 to 4 of the Exercise regime

    Physical function

  • Concentration of glucose

    Day after the Exercise regime

  • Concentration of insulin

    Day after the Exercise regime

  • Concentration of total cholesterol

    Day after the Exercise regime

  • Concentration of high density lipoprotein cholesterol (HDL-cholesterol)

    Day after the Exercise regime

  • Concentration of low density lipoprotein cholesterol (LDL-cholesterol)

    Day after the Exercise regime

  • Concentration of non-high densitiy lipoprotein cholesterol (non-HDL cholesterol)

    Day after the Exercise regime

  • Concentration of triglyceride

    Day after the Exercise regime

  • Concentration of apolipoprotein A1 (apo A1)

    Day after the Exercise regime

  • Concentration of apolipoprotein B (apo B)

    Day after the Exercise regime

  • Concentration of free fatty acids (FFA)

    Day after the Exercise regime

  • Concentration of C-reactive protein (CRP)

    Day after the Exercise regime

  • Concentration of interleukin 1 (IL-1)

    Day after the Exercise regime

    Immune response

  • Concentration of interleukin 6 (IL-6)

    Day after the Exercise regime

    Immune response

Other measures (8)

  • Blood pressure

    Day after the Control regime

  • Body weight

    Day after the Control regime

    Walking and mobility

  • Blood pressure

    Day after the Sit regime

  • Body weight

    Day after the Sit regime

    Walking and mobility

  • Blood pressure

    Day after the Sit Less regime

  • Body weight

    Day after the Sit Less regime

    Walking and mobility

  • Blood pressure

    Day after the Exercise regime

  • Body weight

    Day after the Exercise regime

    Walking and mobility

Who could take part

MS (type not specified) · 18 to 75

Show the full criteria

Inclusion criteria

* Signed informed consent * Men and women ≥18 years old * Clinical diagnosis of MS (McDonald criteria) * Expanded Disability Status Score ≤ 5 * Daily internet access

Exclusion criteria

* Reported participation in another biomedical trial which may have an effect on blood parameters one month before the pre-study examination or during the study * Blood donation in the past three months * Pregnancy or intention of becoming pregnant * Reported dietary habits: medically prescribed diet, slimming diet * Reported weight loss (>2kg) in the last three months prior to the screening * Alcohol use > 20 units per week (during the last 3 months) * Experimental drug use (during the last 3 months) * Medication changes (during the last month) * Medical conditions which make participation in the study not responsible: * Heart failure: New York Heart Association (NYHA) 3 or higher * Angina pectoris or signs of cardiac ischemia during exercise testing * Mental or physical disability * Based on historical information not able to walk for 3h per day and stand for 4h per day (e.g. intermittent claudication)

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

This study evaluates the impact of reducing sitting time and increasing exercise time on cardiometabolic health in persons with Multiple Sclerosis.

Papers

Loading reviews and guidelines…

History

    1. Started

      Apr 2019

    2. Main results due

      Apr 2021

    3. Finished

      Apr 2021

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