RIPC on Activity, Fatigue and Gait in MS

Role of Remote Ischaemic Preconditioning on Activity, Fatigue and Gait in People With Multiple Sclerosis.

CompletedNot a drug-phase studyMS (type not specified)NCT03967106

We could not find results for this trial

What it found

No results found

We found no results in the registry or in papers.

This trial finished 3 years ago. We found no results in the registry or in any paper that cites it.

What was tested

Treatment tested

  • Ischaemic Preconditioning

Placebo

  • Sham

What it measured

Main measures

  • Change from baseline in speed of walking over a one week period

    7 weeks

    Walking and mobility

  • Change from baseline in number of steps taken over a one week period

    7 weeks

  • Change from baseline in length of stride over a one week period

    7 weeks

  • Change from baseline in speed of walking during the 6 minute walk test

    6 weeks

    Walking and mobilityPhysical function

  • Change from baseline in Modified Fatigue Impact Scale (MFIS) Score

    6 weeks

    Thinking and memoryFatigue

  • Change from baseline in Multiple Sclerosis Walking Scale 12 (MSWS-12) score

    6 weeks

    Walking and mobility

  • Change from baseline in Borgs rating of perceived exertion scale score

    6 weeks

    Walking and mobility

Who could take part

MS (type not specified) · 18 and over

Show the full criteria

Inclusion criteria

* Diagnosis of MS as per the McDonald's criteria * Sufficient cognitive ability and understanding of the English language to give informed consent and complete study questionnaires * Ability to walk for 6 minutes without rest * Resting Systolic BP of more than 100mmHg * Resting Systolic BP of less than 170mmHg

Exclusion criteria

* Cognitive difficulties or insufficient English to allow understanding of consent and study questionnaires * Inability to walk * Other systemic illness affecting exercise tolerance * Resting Systolic BP of less than 100mmHg * Resting systolic BP of 170mmHg or more

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

This study evaluates whether Remote Ischaemic Preconditioning (RIPC) can improve activity, gait and fatigue in people with Multiple Sclerosis. Half the participants will receive RIPC, the other half will receive a sham treatment.

Papers

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    History

      1. Started

        Aug 2019

      2. Main results due

        Mar 2023

      3. Finished

        Mar 2023

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