Isoelectric Focusing of Tears in Children With Radiologically Isolated
Detecting Oligoclonal Bands Through Isoelectric Focusing of Tears in Children With Radiologically Isolated Syndrome or Clinically Isolated Syndrome: a Diagnostic, Prospective, Multicentric Study With a 2-year Longitudinal Follow-up
We could not find results for this trial
What it found
We found no results in the registry or in papers.
What was tested
Treatment tested
- Tear collection and lumbar punction
What it measured
Main measures
Sensitivity of tears analysis compared to lumbar punction analysis for the diagnosis of CIS and RIS
Day 0
Specificity of tears analysis compared to lumbar punction analysis for the diagnosis of CIS and RIS
Day 0
Positive predictive value of tears analysis compared to lumbar punction analysis for the diagnosis of CIS and RIS
Day 0
Negative predictive value of tears analysis compared to lumbar punction analysis for the diagnosis of CIS and RIS
Day 0
Other measures (1)
Proportion of patients with OCBs in tears
day 0, one year
Who could take part
Early (CIS/RIS) · Up to 18
Show the full criteria
Inclusion criteria
* age \< 18 years old * informed consent from the child and the parents (at least one of the two legal guardians) * child covered by social security For the RIS population: * asymptomatic child * fortuitous discovery of lesions strongly suggesting sclerosis multiple on a Magnetic resonance imaging (MRI) scan For the CIS population: - child presenting a CIS in the past three months
Exclusion criteria
* patient with remitting MS * patient with progressive MS * patient with eye infection * patient under immunosuppressive therapy on the day of inclusion due to the treatment of another disease than MS
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The main gold of this study is to lead a multicentric, prospective study, to evaluate the diagnostic quality of tears in children with clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) during a longitudinal follow-up.
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History
Started
Sept 2019
Main results due
Nov 2024
Finished
Nov 2024