Evaluation of a Theory-Driven Manualized Approach to Improving New Lea
Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in MS
What it found
We found no results in the registry or in papers.
What was tested
Treatment tested
- Strategy-Based Training to Enhance Memory (STEM)
Placebo
- Placebo control exercises
What it measured
Main measures
Changes in scores on self-report measure of everyday cognition (subjective)
Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Thinking and memoryChanges in scores on self-report measure of everyday cognition (objective)
Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Thinking and memory
Other measures (7)
Changes in auditory processing speed
Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Thinking and memoryChanges in information processing speed
Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Thinking and memoryChanges in episodic verbal memory and learning
Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Thinking and memoryChanges in visuospatial memory
Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Thinking and memoryChanges in ability in spontaneous production of words
Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in visual perception
Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Changes in executive function
Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Who could take part
Relapsing and progressive · 18 to 59
Show the full criteria
Inclusion criteria
* Diagnosis of Multiple Sclerosis * Ability to read and speak English fluently * Difficulties with learning and memory skills
Exclusion criteria
* Prior diagnosis of stroke or other neurological injury/disease * Flare up of symptoms within a month of study participation * History of significant psychiatric illness (e.g., bipolar disorder, schizophrenia, psychosis) or current diagnosis of Major Depressive Disorder, Schizophrenia, Bipolar Disorder I or II * Current significant alcohol or substance abuse * Taking exclusionary medication (study team will review medications) For Optional MRI: * Pacemaker or other implanted electrical device, brain stimulator, aneurysm clip (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and internal hearing aids [cochlear implants]), permanent eyeliner, implanted delivery pumps, or shrapnel fragments. * Dental implants * Left-handed
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons with Multiple Sclerosis.
Papers
Loading reviews and guidelines…
History
Started
Sept 2019
Main results due
Dec 2025
Finished
Dec 2025