A Randomized Trial on the Novel Use of Treadmill Plus Music in Multiple Sclerosis Patients With Gate Impairnent

Status unknownNot a drug-phase studyRelapsing MSNCT04019912

What it found

Paper found, not read

A paper reports the results; we have not read it yet. See Papers below.

What was tested

Treatment tested

  • Gait Training plus music

Compared with

  • Traditional Gait Training

What it measured

Main measures

  • Ten-metre walking test

    3 months

    Walking and mobility
  • Timed up-and-go test

    3 months

    Walking and mobility

Other measures (2)

  • Gait Quality Index

    3 months

    Walking and mobility
  • Multiple Sclerosis Quality of Life-54

    3 months

    Thinking and memoryFatigueBladder, bowel and sexual functionPainQuality of life (reported by participants)

Who could take part

Relapsing MS · 18 to 75

Show the full criteria

Inclusion criteria

* Diagnosis of relapsing remitting MS according to Polman criteria; * presence of gait impairment; * absence of auditory deficits; * EDSS \<4.5; * absence of clinical and/or neuroradiological MS relapse in the 3 months before enrolment; * stable therapy in the last 3 months.

Exclusion criteria

* presence of bone or joint disorders; * history of severe cardiovascular, respiratory, auditory, and muscular-skeletal disease; * other neurological conditions; and neurologic music therapy in the last 3 month; * MS relapse in the 6 months before enrolment; * Expanded Disability Status Scale (EDSS) > 4.5.

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

Multiple sclerosis (MS) is characterized by demyelination andaxonal loss of the central nervous system, which progressively results in neurologic dysfunction and is often accompanied by gaite limitations, reduced fitness, and increased risk of falls. Traditional exercises such as treadmill walking orstationary cycling can often be perceived as boring, because theseexercises usually involve repetitive, continuous movements. In recents years the positive effect of the auditory stimulus in the recovery of gait difficulties has been demonstrated in Parkinson's disease, however this methodology on MS patients has been poorly investigated. In addiction the neurophysiological mechanisms by which coupling steps with external auditory cues improves gait remain partially unclear. For this reason, our purpose is to investigate whether patients with MS, compared to the control group, may have improvements in motor and psychological well-being, through training with devices that integrate motor training with musical stimuli (Gait trainer).

Papers

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History

    1. Started

      Oct 2019

    2. Main results due

      Mar 2020

    3. Finished

      May 2020

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