Cerebral Blood Flow and tDCS
Cerebral Blood Flow in People With Multiple Sclerosis During Transcranial Direct Current Stimulation
What it found
We found no results in the registry or in papers.
This trial finished 6 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- tDCS
What it measured
Main measures
Cerebral Blood Flow
Through study completion, an average of 1 year
Who could take part
MS (type not specified) · 18 to 65
Show the full criteria
Inclusion criteria
* Confirmed diagnosis of multiple sclerosis by a neurologist * No change in MS-specific medication (disease modification drugs) in the last three months * Healthy enough to complete the protocol based on information obtained from a clinical exam and past medical history. * An expanded disability status scale (EDSS) below 5.5 * Comprehension of the protocol as indicated by an ability to respond to questions about the study after reading the consent form. * Able to use and be contacted by telephone * Able to speak, read, and understand English, and complete a questionnaire in English * Body mass index \<30 kg/m2
Exclusion criteria
* A relapse of disease symptoms in the last three months * History / presence of secondary conditions such as seizure disorders (or on medications known to lower seizure threshold), hydrocephalus, diabetes mellitus, or claustrophobia * Alcohol dependence or abuse (>2 drinks/day), or present history (last six months) of drug abuse * History of significant traumatic brain injury or hydrocephalus * Currently pregnant * Recent hospitalization (within the last 3 months) or enforced bed rest/sedentary state * Claustrophobia A subject will be excluded if he/she has a contraindication to Magnetic Resonance scanning, e.g., implanted metal clips or wires, which may concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field. Examples include: * Aneurysm clip * Implanted neural stimulator * Implanted cardiac pacemaker or autodefibrillator * Cochlear implant * Ocular foreign body (e.g., metal shavings) * Any implanted device (pumps, infusion devices, etc.) * Shrapnel injuries
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
With this study, the investigators will substantiate if regional cerebral blood flow (CBF) is affected by tDCS, assess the amount of CBF change in relation to different currents, and measure differences in regional CBF under stimulation reactivity between healthy subjects and people with Multiple Sclerosis (PwMS)using Water O-15 PET (Water Oxygen-15 Positron EmissionTomography) imaging. The objective is to investigate the changes in regional CBF after transcranial direct current stimulation (tDCS) at different intensities (1 mA, 2 mA, 3 mA, 4 mA) in healthy subjects and PwMS. The design is a cross-sectional proof of principle study in 10 healthy subjects and 10 PwMS. Relative regional brain CBF (rCBF) will be analyzed semi-quantitatively using voxel-wise and region of interest-based approaches. Changes in CBF associated with tDCS-application will be calculated with a general linear model in a ramp function of the task-specific rCBF, according to previous work in our group using a glucose analogue. Exploratory statistical testing will be done using a paired samples t-test between task and rest conditions and unpaired t-tests between PwMS and healthy controls at the same intensities. With this study the investigators will be able to dose-dependently measure real-time rCBF changes after non-invasively stimulating the superficial parts of the dorsolateral prefrontal cortex (DLPFC), a commonly used target in therapeutic tDCS applications. This will provide further insight into whether tDCS is capable of inducing changes in rCBF.
Papers
Loading reviews and guidelines…
History
Started
Dec 2019
Main results due
Aug 2020
Finished
Aug 2020