The Impact of Training on Sitting Time and Brain Volumes in Multiple S
The Impact of Structured Exercise on Physical Fitness, Sedentary Time, Brain Volume, Cognitive, Health-related and Immunological Parameters in Multiple Sclerosis.
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Periodized, home-based running program
What it measured
Main measures
Number of steps per day
Before start of the training program
Physical functionNumber of steps per day
Week 1 of the training program
Physical functionNumber of steps per day
Week 24 of the training program
Physical functionNumber of steps per day
Week 48 of the training program
Physical functionNumber of steps per day
3 months after the training program
Physical functionSitting time
Before start of the training program
Physical functionSitting time
Week 1 of the training program
Physical functionSitting time
Week 24 of the training program
Physical functionSitting time
Week 48 of the training program
Physical functionSitting time
3 months after the training program
Physical functionStanding time
Before start of the training program
Physical functionStanding time
Week 1 of the training program
Physical functionStanding time
Week 24 of the training program
Physical functionStanding time
Week 48 of the training program
Physical functionStanding time
3 months after the training program
Physical functionStepping time
Before start of the training program
Physical functionStepping time
Week 1 of the training program
Physical functionStepping time
Week 24 of the training program
Physical functionStepping time
Week 48 of the training program
Physical functionStepping time
3 months after the training program
Physical function
Other measures (62)
Blood pressure
Baseline
Blood pressure
Week 48 of the training program
Resting heart rate
Baseline
Resting heart rate
Week 48 of the training program
Total calorie intake
Baseline
Total calorie intake
Week 12 of the training program
Total calorie intake
Week 24 of the training program
Total calorie intake
Week 48 of the training program
Total calorie intake
3 months after the training program
Macronutrient content
Baseline
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* Multiple Sclerosis according to the McDonald criteria (Relaps remitting) * Written informed consent * Medical safety screening
Exclusion criteria
* Contra-indications to participate in moderate to high intensity exercise * Contra-indications to undergo magnetic resonance imaging (pacemaker/defibrillator or wires other than sternal wires, insulin pumps, metal foreign bodies, deep brain stimulator, cerebral aneurysm clips, cochlear implant, magnetic dental implant, drug infusion device) * Medication changes in the last month before the start of the intervention * Following or plan to follow a weight reduction program * Pregnancy * Participation in another study * Acute MS exacerbation \< 3 months prior to the start of the study * EDSS score > 4 * Consumption of more than 20 alcohol units/week * No daily internet access
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The current study aims to investigate whether persons with Multiple Sclerosis (PwMS) compensate training time with more sedentary time and consequently blunt training effects. The second aim will be to investigate the effect of a structured training program on specific brain volumes and cognitive variables.
Papers
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History
Started
Jan 2020
Main results due
Jun 2021
Finished
Jun 2021