Virtual Reality Approach in Multiple Sclerosis

Main measures

• Change in range of motion from baseline to week 4

  4 weeks

  Arm and hand function

• Change in level of pain from baseline to week 4

  4 weeks

  Pain

• Change in disability of the upper extremity from baseline to week 4

  4 weeks

  Arm and hand function

• Change in pain threshold from baseline to week 4

  4 weeks

  Pain

• Change in proprioception from baseline to week 4

  4 weeks

  Physical function

• Change in kinesiophobia from baseline to week 4

  4 weeks

  Physical functionBladder, bowel and sexual function

• Satisfaction of the Treatment

  4 weeks

  PainQuality of life (reported by participants)

• Change in muscle strength from baseline to week 4

  4 weeks

  Physical function

• Change in disability of the fingers from baseline to week 4

  4 weeks

  Disability progressionArm and hand function

• Change in spasticity from baseline to week 4

  4 weeks

  Spasticity

MS (type not specified) · 18 to 65

As registered. Criteria can change, so ask the trial team or your neurologist.

In the sponsor's words

• Background

  Bao X, Mao Y, Lin Q, Qiu Y, Chen S, Li L, Cates RS, Zhou S, Huang D. Mechanism of Kinect-based virtual reality training for motor functional recovery of upper limbs after subacute stroke. Neural Regen Res. 2013 Nov 5;8(31):2904-13. doi: 10.3969/j.issn.1673-5374.2013.31.003.

• Background

  Arman N, Tarakci E, Tarakci D, Kasapcopur O. Effects of Video Games-Based Task-Oriented Activity Training (Xbox 360 Kinect) on Activity Performance and Participation in Patients With Juvenile Idiopathic Arthritis: A Randomized Clinical Trial. Am J Phys Med Rehabil. 2019 Mar;98(3):174-181. doi: 10.1097/PHM.0000000000001001.

• Background

  Burdea GC. Virtual rehabilitation--benefits and challenges. Methods Inf Med. 2003;42(5):519-23.

• Background

  Rubin BD, Kibler WB. Fundamental principles of shoulder rehabilitation: conservative to postoperative management. Arthroscopy. 2002 Nov-Dec;18(9 Suppl 2):29-39. doi: 10.1053/jars.2002.36507. No abstract available.

• Background

  Chen CC. Multimedia virtualized environment for shoulder pain rehabilitation. J Phys Ther Sci. 2016 Apr;28(4):1349-54. doi: 10.1589/jpts.28.1349. Epub 2016 Apr 28.

• Background

  Andrews AW, Thomas MW, Bohannon RW. Normative values for isometric muscle force measurements obtained with hand-held dynamometers. Phys Ther. 1996 Mar;76(3):248-59. doi: 10.1093/ptj/76.3.248.

• Background

  Bjartmar C, Trapp BD. Axonal and neuronal degeneration in multiple sclerosis: mechanisms and functional consequences. Curr Opin Neurol. 2001 Jun;14(3):271-8. doi: 10.1097/00019052-200106000-00003.

• Background

  Crayton H, Heyman RA, Rossman HS. A multimodal approach to managing the symptoms of multiple sclerosis. Neurology. 2004 Dec 14;63(11 Suppl 5):S12-8. doi: 10.1212/wnl.63.11_suppl_5.s12.

• Background

  Earhart GM, Cavanaugh JT, Ellis T, Ford MP, Foreman KB, Dibble L. The 9-hole PEG test of upper extremity function: average values, test-retest reliability, and factors contributing to performance in people with Parkinson disease. J Neurol Phys Ther. 2011 Dec;35(4):157-63. doi: 10.1097/NPT.0b013e318235da08.

• Background

  Feys P, Helsen W, Liu X, Mooren D, Albrecht H, Nuttin B, Ketelaer P. Effects of peripheral cooling on intention tremor in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2005 Mar;76(3):373-9. doi: 10.1136/jnnp.2004.044305.

1. Started

   Jan 2020

2. Main results due

   Jun 2021

3. Finished

   Jun 2021