Evaluation of the Impact of Lesions of the Motor and Proprioceptive Br
Evaluation of the Impact of Lesions of the Motor and Proprioceptive Brain and Pan-medullary Pathways on Their Clinically and Electrophysiologically Assessed Function in Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- MRI
- Electrophysiology
What it measured
Main measures
association ratio between EDSS score and focal injury fraction at inclusion
24 months
Disability progressionMRI lesions
Other measures (12)
Correlation between focal lesion load and changes in Expanded Disability Status Scale (EDSS)
24 months
Disability progressionMRI lesionsCorrelation between the severity of lesions and changes in Expanded Disability Status Scale (EDSS)
24 months
Disability progressionMRI lesionsMyelin repairDifferences in central conduction times between patients and healthy volunteers
1 day
Myelin repairCorrelation between focal lesion load and changes in Timed 25-Foot Walk Test (T25W)
24 months
Disability progressionMRI lesionsWalking and mobilityCorrelation between the severity of lesions and changes in Timed 25-Foot Walk Test (T25W)
24 months
Disability progressionMRI lesionsMyelin repairWalking and mobilityCorrelation between focal lesion load and changes in Nine Hole Peg Test (9HPT)
24 months
Disability progressionMRI lesionsArm and hand functionCorrelation between the severity of lesions and changes in Nine Hole Peg Test (9HPT)
24 months
Disability progressionMRI lesionsMyelin repairArm and hand functionCorrelation between focal lesion load and changes in walking distance
24 months
MRI lesionsWalking and mobilityCorrelation between the severity of lesions and changes in walking distance
24 months
MRI lesionsMyelin repairWalking and mobilityCorrelation between focal lesion load and changes in 12-Item Multiple Sclerosis Walking Scale (MSWS12) score
24 months
MRI lesionsWalking and mobilityPainMood and sleepQuality of life (reported by participants)
Who could take part
Relapsing MS · 18 and over · EDSS 0 to 4
Show the full criteria
Inclusion criteria
Patients : * More than 18 years old * relapsing-remitting multiple sclerosis according to Mac Donald criteria (2010) * EDSS score at the inclusion from 0 to 4 * With at least 1 symptom of pyramidal injury during clinical exam * Written informed consent * Affiliated to a Health Care system Healthy Volunteers: * More than 18 years old * Written informed consent * Affiliated to a Health Care system
Exclusion criteria
Patients * progressive MS ; * Corticoids during the last 60 days before inclusion ; * Other neurological disease or Other progressive systemic disease * adults subject to legal protection or persons deprived of liberty * Contraindications to MRI * Contraindications to motor evoked potentials * Current pregnancy or breast-feeding Healthy volunteers: * History of disease affecting central nervous system * Familial history of MS * History of medullar injury * Spinal osteoarthritis which can lead to a spinal hypersignal ; * adults subject to legal protection or persons deprived of liberty * Contraindications to MRI * Contraindications to motor evoked potentials * Current pregnancy or breast-feeding
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Multiple Sclerosis (MS) is the most common acquired neurological disease leading to disability, especially ambulatory, in young adults. To date, the correlation between the number or volume of white matter lesions seen on conventional MRI and the degree of disability of patients remains low to moderate. This phenomenon is known as the "clinical-radiological paradox". In this new project, we hypothesize that an evaluation of the corticospinal pathways including their thoracic medullary portion, as well as taking into account the severity of the lesions using quantitative MRI, will allow the investigators to refine the correlation with ambulatory disability in MS patients. We will complete the evaluation of motor pathways with those of the proprioceptive pathways also strongly involved in ambulation.
Papers
Loading reviews and guidelines…
History
Started
Nov 2020
Main results due
Oct 2023
Finished
Nov 2025