Neuroproprioceptive "Facilitation, Inhibition" and Brain Plasticity
Neuroproprioceptive Facilitation and Inhibition Physical Therapy Activates Adaptive and Plastic Changes in the Central Nervous System
What it found
Results are posted in the registry, but without a statistical test of the main measure. See the numbers below.
What was tested
Treatment tested
- Motor program activating therapy
- Vojta's reflex locomotion
- Functional electric stimulation
Results by group
White Matter Integrity
2 months
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Motor Program Activating Therapy | 0.5023 score on a scale | 0.0293 (Standard Deviation) | 42 |
| Vojta's Reflex Locomotion | 0.5168 score on a scale | 0.0266 (Standard Deviation) | 29 |
| Functional Electric Stimulation | 0.4747 score on a scale | 0.0293 (Standard Deviation) | 21 |
Motor Program Activating Therapy
Vojta's Reflex Locomotion
Functional Electric Stimulation
Values as posted on ClinicalTrials.gov. Outcomes measured differently across trials are not directly comparable.
Safety
| Group | Participants at risk | Serious adverse events | Deaths |
|---|---|---|---|
| Vojta's Reflex Locomotion | 29 | 0 (0.0%) | 0 |
| Motor Program Activating Therapy | 42 | 0 (0.0%) | 0 |
| Functional Electric Stimulation | 21 | 1 (4.8%) | 0 |
As posted on ClinicalTrials.gov. Serious adverse events include any serious health event during the trial, whether or not the treatment caused it.
What it measured
Main measures
White Matter Integrity
2 months
MRI lesions
Other measures (4)
Berg Balance Scale, BBS
2 months
Walking and mobilityTimed up and go Test, TUG
2 months
Walking and mobilitythe 12-item Multiple Sclerosis Walking Scale, MSWS - 12
2 months
Walking and mobilitythe 29-item Multiple Sclerosis Impact Scale, MSIS -29
2 months
Quality of life (reported by participants)
Who could take part
MS (type not specified) · 18 to 70
Show the full criteria
Inclusion criteria
* prevailed spastic paraparesis, stable clinical status and treatment in the preceding 3 months determined by neurologist, * Expanded Disability Status Scale score (EDSS) max. 7.5
Exclusion criteria
* other neurological disease or conditions disabling movement
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study investigates whether neuroproprioceptive "facilitation, inhibition" physical therapy induces plastic and adaptive processes of the CNS (white matter integrity changes), if they relate to clinical improvement, and whether therapeutic effect differs between different kinds of therapies.
Papers
Results
A Three-Arm Parallel-group Exploratory Trial documents balance improvement without much evidence of white matter integrity changes in people with multiple sclerosis following two months ambulatory neuroproprioceptive "facilitation and inhibition" physical therapy.Eur J Phys Rehabil Med · 2021
Loading reviews and guidelines…
History
Started
May 2015
Main results due
May 2017
Finished
Aug 2019
Results posted
Jul 2020