Short Arm Human Centrifuge Therapeutic Training and Rehabilitation (GR

Main measures

• Cardiovascular physiological parameter 1 cardiac output (CO) 1-standing

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 1 cardiac output (CO) 2-lying

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 1 cardiac output (CO) 3-mild intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 1 cardiac output (CO) 4-medium intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 1 cardiac output (CO) 5-high intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 2, Stroke volume (SV) 1-standing

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 2, Stroke volume (SV) 2-lying

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 2, Stroke volume (SV) 3-mild intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 2, Stroke volume (SV) 4-medium intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 2, Stroke volume (SV) 5-high intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 3, mean arterial pressure (MAP) 1-standing

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 3, mean arterial pressure (MAP) 2-lying

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 3, mean arterial pressure (MAP) 3-mild intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 3, mean arterial pressure (MAP) 4-medium intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 3, mean arterial pressure (MAP) 5-high intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 4, diastolic blood pressure (DBP) 1-standing

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 4, diastolic blood pressure (DBP) 2-lying

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 4, diastolic blood pressure (DBP) 3-low intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 4, diastolic blood pressure (DBP) 4-medium intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 4, diastolic blood pressure (DBP) 5-high intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 5, systolic blood pressure (SBP) 1-standing

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 5, systolic blood pressure (SBP) 2;lying

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 5, systolic blood pressure (SBP) 3-mild intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 5, systolic blood pressure (SBP) 4-medium intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 5, systolic blood pressure (SBP) 5-high intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 6, heart rate (HR) 1-standing

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 6, heart rate (HR) 2-lying

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 6, heart rate (HR) 3-mild intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 6, heart rate (HR) 4-medium intensity

  The time frame will include: changes from baseline up to 6 months

• Cardiovascular physiological parameter 6, heart rate (HR) 5-high intensity

  The time frame will include: changes from baseline up to 6 months

• Electrical activity of the brain in alpha band, Electroencephalography (EEG)(μV) 1

  The time frame will include: changes from baseline up to 6 months

  Nerve conduction tests

• Electrical activity of the brain in alpha band, Electroencephalography (EEG)(μV) 2

  The time frame will include: changes from baseline up to 6 months

  Nerve conduction tests

• Electrical activity of the brain in alpha band, Electroencephalography (EEG)(μV) 3

  The time frame will include: changes from baseline up to 6 months

  Nerve conduction tests

• Electrical activity of the brain in alpha band, Electroencephalography (EEG)(μV) 4

  The time frame will include: changes from baseline up to 6 months

  Nerve conduction tests

• Electrical activity of the brain in alpha band, Electroencephalography (EEG)(μV) 5

  The time frame will include: changes from baseline up to 6 months

  Nerve conduction tests

• Electrical activity of the brain in alpha band, Electroencephalography (EEG)(μV) 6

  The time frame will include: changes from baseline up to 6 months

  Nerve conduction tests

• Electrical activity of the brain in alpha band, Electroencephalography (EEG)(μV) 7

  The time frame will include: changes from baseline up to 6 months

  Nerve conduction tests

• The Short Physical Performance Battery assessment score

  The time frame will include: changes from baseline up to 6 months

  Walking and mobilityPhysical function

• The Functional Gait Assessment (FGA)

  changes in 3 months

  Walking and mobility

• Gastrocnemius muscle oxygenation

  The time frame will include: changes in 3 months

• Biological samples 1: CATECHOLAMINES

  The time frame will include: changes in 3 months

• Biological samples 2: ADIPONECTINE

  The time frame will include: changes in 3 months

• Biological samples 3:BDNF

  The time frame will include: changes in 3 months

• Biological samples 4:MELATONINE

  The time frame will include: changes in 3 months

• Biological samples 5:ADENOSINE

  The time frame will include: changes in 3 months

• Biological samples 5:TNF-α

  The time frame will include: changes in 3 months

• Biological samples 6:IL-1β

  The time frame will include: changes in 3 months

  Immune response

• Biological samples 7:High-sensitivity C-reactive Protein (hs-CRP)

  The time frame will include: changes in 3 months

• Biological samples 8:Total leucocyte number:

  The time frame will include: changes in 3 months

• Biological samples 9:sTNF-RII

  The time frame will include: changes in 3 months

• Biological samples 10:D-creatinine

  The time frame will include: changes in 3 months

• Biological samples 11:alpha-amylase

  The time frame will include: changes in 3 months

• Biological samples 12:secretory immunoglobulin A (sIgA)

  The time frame will include: changes in 3 months

• Biological samples 13: cortisol (SC) mg/dL

  The time frame will include: changes in 3 months

• Biological samples 14: Glucose

  The time frame will include: changes in 3 months

• Biological samples 15: ACTH

  The time frame will include: changes in 3 months

• Biological samples 16: Transcortin (mg/liter)

  The time frame will include: changes in 3 months

• Biological samples 17: Total antioxidant capacity (TAC)

  The time frame will include: changes in 3 months

• weight in kilograms, height in meters), as appropriate, or to clarify how multiple measurements will be aggregated to arrive at one reported value (e.g., weight

  changes in 3 months

• Height

  Day 1only

• Body Mass Index

  changes in 3 months

MS (type not specified) · 17 to 90

As registered. Criteria can change, so ask the trial team or your neurologist.

In the sponsor's words

• Results

  Chriskos P, Frantzidis CA, Gkivogkli PT, Bamidis PD, Kourtidou-Papadeli C. Automatic Sleep Staging Employing Convolutional Neural Networks and Cortical Connectivity Images. IEEE Trans Neural Netw Learn Syst. 2020 Jan;31(1):113-123. doi: 10.1109/TNNLS.2019.2899781. Epub 2019 Mar 15.

• Results

  LeBlanc A, Gogia P, Schneider V, Krebs J, Schonfeld E, Evans H. Calf muscle area and strength changes after five weeks of horizontal bed rest. Am J Sports Med. 1988 Nov-Dec;16(6):624-9. doi: 10.1177/036354658801600612.

• Results

  Habazettl H, Stahn A, Nitsche A, Nordine M, Pries AR, Gunga HC, Opatz O. Microvascular responses to (hyper-)gravitational stress by short-arm human centrifuge: arteriolar vasoconstriction and venous pooling. Eur J Appl Physiol. 2016 Jan;116(1):57-65. doi: 10.1007/s00421-015-3241-6. Epub 2015 Aug 18.

• Results

  Katzmarzyk PT, Church TS, Craig CL, Bouchard C. Sitting time and mortality from all causes, cardiovascular disease, and cancer. Med Sci Sports Exerc. 2009 May;41(5):998-1005. doi: 10.1249/MSS.0b013e3181930355.

• Results

  Diaz-Artiles A, Heldt T, Young LR. Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise. Front Physiol. 2018 Nov 13;9:1492. doi: 10.3389/fphys.2018.01492. eCollection 2018.

• Results

  Manen O, Dussault C, Sauvet F, Montmerle-Borgdorff S. Limitations of stroke volume estimation by non-invasive blood pressure monitoring in hypergravity. PLoS One. 2015 Mar 23;10(3):e0121936. doi: 10.1371/journal.pone.0121936. eCollection 2015.

• Results

  Truijen J, van Lieshout JJ, Wesselink WA, Westerhof BE. Noninvasive continuous hemodynamic monitoring. J Clin Monit Comput. 2012 Aug;26(4):267-78. doi: 10.1007/s10877-012-9375-8. Epub 2012 Jun 14.

• Results

  van der Spoel AG, Voogel AJ, Folkers A, Boer C, Bouwman RA. Comparison of noninvasive continuous arterial waveform analysis (Nexfin) with transthoracic Doppler echocardiography for monitoring of cardiac output. J Clin Anesth. 2012 Jun;24(4):304-9. doi: 10.1016/j.jclinane.2011.09.008.

• Results

  Verma AK, Xu D, Bruner M, Garg A, Goswami N, Blaber AP, Tavakolian K. Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge. Front Physiol. 2018 Jun 25;9:712. doi: 10.3389/fphys.2018.00712. eCollection 2018.

• Results

  Wang YC, Yang CB, Wu YH, Gao Y, Lu DY, Shi F, Wei XM, Sun XQ. Artificial gravity with ergometric exercise as a countermeasure against cardiovascular deconditioning during 4 days of head-down bed rest in humans. Eur J Appl Physiol. 2011 Sep;111(9):2315-25. doi: 10.1007/s00421-011-1866-7. Epub 2011 Feb 20.

1. Nov 2026Status changed from Running, not recruiting to Status unknown

1. Started

   Feb 2020

2. Main results due

   Mar 2021

3. Finished

   Dec 2025