Feasibility of a High-intensity Interval Training Program in Persons W
A Single-group, Feasibility, and Initial Efficacy Study of a High-intensity Interval Training Program Using Adaptive Equipment in Persons With Multiple Sclerosis Who Have Walking Disability
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Recumbent Stepping, High-Intensity Interval Training
What it measured
Main measures
Recruitment, Retention, and Adherence Rates
From recruitment to end of treatment at 12 weeks.
Quality of life (reported by participants)FeasibilityTime Needs
From recruitment to end of treatment at 12 weeks.
Monetary Needs
From recruitment to end of treatment at 12 weeks.
Data Management and Safety Reporting
From recruitment to end of treatment at 12 weeks.
SafetyParticipant Burden Reporting
From recruitment to end of treatment at 12 weeks.
Safety Reporting
From recruitment to end of treatment at 12 weeks.
Safety
Other measures (8)
Change in Aerobic Capacity
Week 0, Following Week 6, Following Week 12
Physical functionChange in 6-Minute Walk Distance
Week 0, Following Week 6, Following Week 12
Walking and mobilityChange in 25-Foot Walk Speed
Week 0, Following Week 6, Following Week 12
Walking and mobilityChange in Sedentary, Light, and Moderate-to-Vigorous Counts of Physical Activity
Week 0, Following Week 6, Following Week 12
Physical functionChange in the Brief International Cognitive Assessment in MS Scores
Week 0, Following Week 6, Following Week 12
Thinking and memoryChange in 9-Hole Peg Test Score
Week 0, Following Week 6, Following Week 12
Disability progressionChange in Fatigue Scores
Week 0, Following Week 6, Following Week 12
FatigueChange in Depressive Symptoms Scores
Week 0, Following Week 6, Following Week 12
Mood and sleep
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* age 18 or over * a self-reported diagnosis of multiple sclerosis * self-reported Expanded Disability Status Scale (EDSS) score \< 8.0 or Patient Determined Disability Steps (PDDS) scale score ≤ 7.0 * relapse free in past 30 days * willing and able to visit Berry College or University of North Texas on three testing occasions and twenty four training occasions * asymptomatic status for maximal exercise testing; (g) physician approval for undertaking exercise testing * a self-reported ability to speak, read, and understand English
Exclusion criteria
* Any persons who do not meet the inclusion criteria
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
There is considerable evidence to support the efficacy of moderate intensity continuous (MIC) exercise benefitting clinically-relevant outcomes in persons with multiple sclerosis (MS). However, persons with MS who have walking impairments (pwMS-wd) are severely deconditioned and may achieve superior benefits by engaging in high-intensity interval training (HIIT), especially while utilizing adaptive equipment, such as with recumbent arm/leg stepping (RSTEP). Of the published studies on HIIT in MS, HIIT yielded significant improvements in cardiorespiratory fitness in all but one study. In those studies that directly compared HIIT to MIC exercise, the data indicated a potential superiority of HIIT as compared to MIC in improving physiological conditioning in a time efficient manner. However, this evidence is specific to those with MS with mild to moderate disability engaging in cycle/arm ergometry and an investigation of HIIT in pwMS-wd is needed as the feasibility and potential benefits of engaging in HIIT in pwMS-wd is relatively unknown. The primary aim of the proposed study is to assess the feasibility of a 12-week, RSTEP HIIT program in pwMS-wd. The secondary aim is to examine changes in aerobic fitness, physical activity, ambulation, upper arm function, cognition, fatigue, and depressive symptoms as clinically-relevant efficacy outcomes following the 12-week, RSTEP HIIT intervention. It is hypothesized that the intervention will be feasible and lead to positive changes in aerobic fitness, physical activity, ambulation, upper arm function, cognition, fatigue, and depressive symptoms. This work is informed by recently published data, which indicate that a single bout of RSTEP HIIT taxes the cardiorespiratory system significantly more than MIC exercise, yet without untoward effects on walking, gait, cognition, mood, or enjoyment. These data suggest that RSTEP HIIT may be an acceptable, safe, and tolerable stimulus for chronic exercise training.
Papers
Loading reviews and guidelines…
History
Started
Dec 2019
Main results due
Dec 2022
Finished
Dec 2022