Non-invasive Transcranial Electrical Stimulation in MS
Effects of Non-invasive Transcranial Electrical Stimulation on Cognition in Patients With Multiple Sclerosis
What it found
Results are posted in the registry, but without a statistical test of the main measure. See the numbers below.
What was tested
Treatment tested
- non-invasive transcranial electrical stimulation
Results by group
Processing Speed Change From Baseline Assessment
Baseline (pre-stim) and post-stimulation (up to 2 hours)
| Group | Value | Interval | Number analysed |
|---|---|---|---|
| Stim2 Low Dose | 41.65 score on a scale | 2.65 (Standard Error) | 20 |
| Stim1 High Dose | 42.05 score on a scale | 2.68 (Standard Error) | 20 |
| Sham Control | 44.4 score on a scale | 1.8 (Standard Error) | 20 |
| Stim2 Low Dose | 46.1 score on a scale | 2.81 (Standard Error) | 20 |
| Stim1 High Dose | 44.8 score on a scale | 2.82 (Standard Error) | 20 |
| Sham Control | 44.8 score on a scale | 1.4 (Standard Error) | 20 |
Values as posted on ClinicalTrials.gov. Outcomes measured differently across trials are not directly comparable.
Safety
| Group | Participants at risk | Serious adverse events | Deaths |
|---|---|---|---|
| Stim1 High Dose | 20 | 0 (0.0%) | 0 |
| Stim2 Low Dose | 20 | 0 (0.0%) | 0 |
| Sham Control | 20 | 0 (0.0%) | 0 |
As posted on ClinicalTrials.gov. Serious adverse events include any serious health event during the trial, whether or not the treatment caused it.
What it measured
Main measures
Processing Speed Change From Baseline Assessment
Baseline (pre-stim) and post-stimulation (up to 2 hours)
Thinking and memoryEVO Performance Change From Baseline Assessment
Baseline (pre-stim) and post-stimulation, up to 2 hours
Thinking and memory
Who could take part
MS (type not specified) · 18 to 65
Show the full criteria
Inclusion criteria
* age 18-65, * diagnosis of MS * Expanded Disability Status Scale (EDSS)≤6.5, no paresis of the upper limbs * a minimum of 3 months since the last relapse * Beck Depression Inventory\<19 * normal hearing * and no changes in MS or symptomatic medications in past 2 months
Exclusion criteria
* prior brain surgery * clips in brain * epilepsy or other neurological or non-affective psychiatric disorders * pregnancy
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The goal is to investigate the effects of non-invasive transcranial electrical stimulation on cognition in MS.
Papers
Results
Effects of transcranial alternating current stimulation on cognitive function in people with multiple sclerosis: A randomized controlled trial.Mult Scler Relat Disord · 2023
Loading reviews and guidelines…
History
Started
Oct 2020
Main results due
Aug 2022
Finished
Aug 2022
Results posted
Dec 2023