Examining the Neural Effects of a Behavioral Intervention for Physical
BIPAMS-Brain:Examining the Neural Effects of a Behavioral Intervention for Physical Activity in Multiple Sclerosis
What it found
We found no results in the registry or in papers.
This trial finished 5 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Behavioral Intervention for Physical Activity in MS (BIPAMS)
Placebo
- Wellness for MS (WellMS)
What it measured
Main measures
Minutes of moderate to vigorous physical activity - Baseline
Assessment will be conducted before the intervention
Physical functionMinutes of moderate to vigorous physical activity - Post intervention
Assessment will be conducted immediately after the intervention
Physical function
Other measures (10)
cardiorespiratory fitness; oxygen consumption during exercise - baseline
Assessment will be conducted before the intervention
Walking and mobilityPhysical functioncardiorespiratory fitness; oxygen consumption during exercise - post intervention
Assessment will be conducted immediately after the intervention
Walking and mobilityPhysical functiondistance walked - baseline
Assessment will be conducted before the intervention
Walking and mobilitydistance walked - post-intervention
Assessment will be conducted immediately after the intervention
Walking and mobilityinformation processing speed; cognitive function - baseline
Assessment will be conducted before the intervention
Thinking and memoryinformation processing speed; cognitive function - post intervention
Assessment will be conducted immediately after the intervention
Thinking and memoryvolume of subcortical grey matter brain structures - baseline
Assessment will be conducted before the intervention
MRI lesionsvolume of subcortical grey matter brain structures - post intervention
Assessment will be conducted immediately after the intervention
MRI lesionsresting state functional brain connectivity - baseline
Assessment will be conducted before the intervention
MRI lesionsNerve conduction testsresting state functional brain connectivity - post intervention
Assessment will be conducted immediately after the intervention
MRI lesionsNerve conduction tests
Who could take part
MS (type not specified) · 18 to 45
Show the full criteria
Inclusion criteria
* diagnosis of multiple sclerosis * relapse free in the last 30 days * being non-active defined as not engaging in regular activity (30 minutes accumulated per day) on more than 2 days of the week during the previous 6 months * ambulate without assistance * low risk for contraindications for MRI
Exclusion criteria
* moderate or high risk for undertaking strenuous or maximal exercise
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Multiple sclerosis [MS] is a prevalent neurological disease that is the leading cause of irreversible neurological disability among young women and the second leading cause of disability among young men in the United States. This disease results in the progressive loss of walking mobility and substantial worsening of cognition, symptoms, and quality of life over time. There is evidence that physical activity is beneficially associated with aerobic fitness and brain structure and function in persons with MS. Nevertheless, this population is strikingly sedentary and physically inactive. This highlights a vital opportunity to improve aerobic fitness and brain health by developing behavioral interventions that increase physical activity. To that end, this project is a Phase-II randomized control trial for examining the efficacy of a behavioral intervention that is based on social-cognitive theory and delivered through the Internet for increasing physical activity and, secondarily, improving aerobic fitness and brain structure and function in persons with MS.
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History
Started
Nov 2020
Main results due
Nov 2021
Finished
Nov 2021