Learning Strategies for Improving Dual Task Performance in Multiple Sc

Learning Strategies for Improving Dual Task Performance in Multiple Sclerosis

CompletedNot a drug-phase studyMS (type not specified)NCT04538872

What it found

No results found

We found no results in the registry or in papers.

This trial finished 5 years ago. We found no results in the registry or in any paper that cites it.

What was tested

Treatment tested

  • StraDiMS implicit
  • StraDiMs explicit

What it measured

Main measures

  • Dual task (STEP + substraction sevens)

    day 2

    Thinking and memory

  • Dual task (STEP + substraction sevens)

    day 4

    Thinking and memory

  • Dual task (STEP + phonetic word list generation)

    day 2

    Thinking and memory

  • Dual task (STEP + phonetic word list generation)

    day 4

    Thinking and memory

  • Dual task (STEP + Auditory vigilance)

    day 2

    Thinking and memory

  • Dual task (STEP + Auditory vigilance)

    day 4

    Thinking and memory

  • Dual Task (WALK + Subtraction sevens)

    day 2

    Thinking and memoryWalking and mobility

  • Dual Task (WALK + Subtraction sevens)

    day 4

    Thinking and memoryWalking and mobility

  • Dual Task (WALK + Word list generation (phonetic)

    day 2

    Thinking and memoryWalking and mobility

  • Dual Task (WALK + Word list generation (phonetic)

    day 4

    Thinking and memoryWalking and mobility

  • Dual Task (WALK + Auditory vigilance)

    day 2

    Thinking and memoryWalking and mobility

  • Dual Task (WALK + Auditory vigilance)

    day 4

    Thinking and memoryWalking and mobility

  • learning measure

    Day 3

  • fNIRS measure (functional near-infrared spectroscopy)

    day 4

    Thinking and memory

Other measures (26)

  • Age

    day 1

  • height

    day 1

  • weight

    day 1

  • educational level questionnaire

    day 1

  • date of diagnosis questionnaire

    day 1

  • type of MS questionnaire

    day 1

  • EDSS

    day 1

    Disability progression

  • Digit span forwards visually

    day 1

  • Brief Visuospatial Memory Test (BVMT)

    day 1

    Thinking and memory

  • 10/36 Spatial Recall test (SPART)

    day 1

Who could take part

MS (type not specified) · 18 to 65 · EDSS 2.0 to 5.5

Show the full criteria

Inclusion criteria

* all participants: minimal cognitive function (MoCA ≥ 26) * Persons with MS: * Diagnosis of MS * EDSS 2.0 - 5.5 * No relapse within the past 30 days. * Able to walk minimally 6 minutes consecutively and to step over the stepping platform without aid.

Exclusion criteria

* Other medical conditions interfering with mobility. * Other neurological conditions. * Not able to understand instructions. * Major (unresolvable) problems with hearing or vision.

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

This study is a randomized controlled study in which we aim to include 60 persons with Multiple Sclerosis and 30 healthy controls. Two different learning strategies, an explicit and an implicit one, will be compared on effects on dual task performance. Further, clinical profile associated with these effects, and brain activity measured by functional near-infrared spectroscopy during dual tasking will be investigated. To this end, the study will cover 4 days: Day 1: examine clinical profile; Day 2: baseline dual task measures; Day 3: experimental learning paradigm with subjects randomly assigned to either the implicit or the explicit learning condition. Day 4: delayed retention dual task and fNIRS measures.

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History

    1. Started

      Sept 2020

    2. Main results due

      Apr 2021

    3. Finished

      Apr 2021

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