Proximal Resistance Training for People With Multiple Sclerosis
Proximal Resistance Training to Improve Walking Capacity and Physical Activity in People With Multiple Sclerosis: A Feasibility Study
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Proximal Resistance Training
What it measured
Main measures
Change in 6-minute walk test
Baseline, end of 10 week intervention period, 22 week follow-up.
Walking and mobility
Other measures (7)
Change in average daily step count
Baseline, end of 10 week intervention period, 22 week follow-up.
Change in movement patterns
Baseline, end of 10 week intervention period, 22 week follow-up.
Walking and mobilityChange in Multiple Sclerosis Walking Scale-12
Baseline, end of 10 week intervention period, 22 week follow-up.
Walking and mobilityChange in Multiple Sclerosis Self-Efficacy Score
Baseline, end of 10 week intervention period, 22 week follow-up.
Change in Exercise Self-Efficacy Scale
Baseline, end of 10 week intervention period, 22 week follow-up.
Physical functionChange in Exercise Stages of Change category
Baseline, end of 10 week intervention period, 22 week follow-up.
Physical functionChange in Modified Fatigue Impact Scale
Baseline, end of 10 week intervention period, 22 week follow-up.
FatigueQuality of life (reported by participants)
Who could take part
MS (type not specified) · 18 to 64
Show the full criteria
Inclusion criteria
Inclusion Criteria. * 18-64 years old * Neurologist-confirmed diagnosis of MS * Able to walk at least 100 meters without an assistive device * Expanded Disability Status Scale - EDSS \< 6 * Have their own tablet/phone/computer capable of video calls/Zoom meetings. Exclusion Criteria. * Other conditions limiting their ability to exercise or walk * Unsafe to exercise as determined by a neurologist or physical therapist * Currently undergoing physical therapy * Unable to provide consent or follow simple directions * Have an MS-related exacerbation or changes to their disease-modifying drug therapy in the month prior to enrollment * A 25 foot walk test time of > 4.5 seconds
Exclusion criteria
Not separately supplied in the registry.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The objective of this study is to pilot a 10-week resistance and functional movement intervention targeting proximal muscles in 40 people with MS. The investigators will assess implementation feasibility (recruitment, fidelity, retention, satisfaction), collect pilot data for key walking function outcomes, and examine movement-pattern and activity behavior mechanisms. Walking function will be measured by walking capacity (6-Minute Walk Test - 6MWT) and PA quantity (average steps/ day over 10 days). Movement-pattern mechanisms will be measured using 3D motion capture analysis (pelvis and trunk kinematics). Activity behavior mechanisms will be measured by patient-reported outcome questionnaires (perception of walking ability, self-efficacy, and readiness to change).
Papers
Loading reviews and guidelines…
History
Started
Oct 2020
Main results due
Oct 2022
Finished
Oct 2022