High-intensity Resistance Training in People With Multiple Sclerosis E
High-intensity Resistance Training in People With Multiple Sclerosis Experiencing Fatigue - Effects on Functioning, Wellbeing and Inflammatory Biological Markers
What it found
We found no results in the registry or in papers.
This trial finished 5 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- High-intensity resistance training
Compared with
- Low frequency of high-intensity resistance training
What it measured
Main measures
Fatigue Scale for Motor and Cognitive Functions
Directly after the intervention (ie change from assessments at baseline to follow-up after the 12 week intervention)
Thinking and memoryFatigue
Other measures (7)
Fatigue Severity Scale
Directly after intervention
FatigueHospital Anxiety and Depression Scale
Directly after the intervention
Mood and sleepOccupational Gaps Questionnaire
Directly after the intervention
Multiple Sclerosis Impact Scale-29
Directly after the intervention
Quality of life (reported by participants)Euroqool five dimension five level
Directly after the intervention
Quality of life (reported by participants)Euroqool visual analogue scale
Directly after the intervention
Quality of life (reported by participants)Multiplex proteomic immunoassay and enzyme-linked immunosorbent assay
Directly after the intervention
Immune response
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* Adults older than 18 years with the diagnosis MS according to the revised McDonald Criteria, having fatigue (i.e. ≥ 53 FSMC sum score), able to understand and communicate in Swedish, and not practicing high-intensity training within 6 months prior to the trial.
Exclusion criteria
* Other conditions or diagnoses judged to potentially interfere with the trial.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Fatigue is one of the most frequently reported and disabling impairments in multiple sclerosis (MS) and is associated with activity limitations, participation restrictions and reduced health-related quality of life (HRQL).MS fatigue is thought to be related to the disease itself, where increased levels of inflammatory biological markers (cytokines) are contributing. Resistance training may have an anti-inflammatory effect where a higher intensity is thought to have a more profound effect. Moderate-intensity resistance training is well tolerated in people with MS (PwMS) and can reduce self-reported fatigue. There is, however, a lack of high-quality studies including only fatigued PwMS when evaluating exercise regimes. Furthermore, the optimal dose (i.e. the combination of duration, frequency and intensity) is not known. Our hypothesis is that high-intensity resistance training will have positive effects in fatigued PwMS on functioning (fatigue, mood, activities and participation) and wellbeing/HRQL; and a positive immunomodulatory effect measured by inflammatory biological markers in blood. Further, that high-intensity resistance training twice a week will be superior to once a week
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History
Started
Aug 2020
Main results due
Jun 2021
Finished
Jun 2022