Auditory-motor Coupling in Multiple Sclerosis With Cerebellar Lesions

Effect of Motor Entrainment to Auditory Cues and Music During Walking on Quality of Movement and Percieved Fatigue in Persons With Multiple Sclerosis With Cerebellar Lesions

CompletedNot a drug-phase studyMS (type not specified)NCT04639401

What it found

Paper found, not read

A paper reports the results; we have not read it yet. See Papers below.

What was tested

Treatment tested

  • motor entrainment to auditory cues and music during walking on quality of movement

What it measured

Main measures

  • Resultant Vector Length

    week 3

  • Resultant Vector Length

    week 4

  • Resultant Vector Length

    week 5

  • Relative phase angle

    week 3

  • Relative phase angle

    week 4

  • Relative phase angle

    week 5

  • Perceptual tempo and rhythm judgements

    week 2

  • Asynchrony

    week2

  • EEG

    week 2

    Nerve conduction tests

  • Muscle weakness

    week 1

    Physical function

  • Spasticity

    week 1

    Spasticity

  • Ataxia

    week 1

    Physical function

  • Dynamic gait index

    week 1

    Walking and mobility

  • Time up and Go test

    week 1

    Walking and mobility

  • 6 minute walking test

    week 1

    Walking and mobility

  • Brief repeatable battery of Rao

    week 1

    Thinking and memory

  • Symbol digit mobility test

    week 1

    Thinking and memoryWalking and mobility

  • Stroop test 0

    week 1

    Thinking and memory

  • MS walking scale -12

    week 1

    Walking and mobility

  • Activities-specific balance confidence scale

    week 1

    Walking and mobility

  • Modified fatigue impact scale

    week 1

    Fatigue

  • Hospital Anxiety and Depression Scale

    week 1

    Mood and sleep

  • Dual task questionnaire

    week 1

Other measures (21)

  • Cadence

    week 3

  • Cadence

    week 4

  • Cadence

    week 5

  • Stride length

    week 3

  • Stride length

    week 4

  • Stride length

    week 5

  • speed

    week 3

    Walking and mobility

  • speed

    week 4

    Walking and mobility

  • speed

    week 5

    Walking and mobility

  • Double Support

    week 3

Who could take part

MS (type not specified) · 18 to 70

Show the full criteria

Inclusion criteria

* diagnosis of Multiple sclerosis >1 year, * type of lesions: cerebellar lesions, * walking speed 0.8-1.2m/s, ability to walk for 6 minutes continuously (canes and rollators are permitted).

Exclusion criteria

* relapse 3 months prior to enrollment, * cognitive impairment impeding understanding of instructions, * beat amusia, * deafness, * pregnancy

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

This study is a case-control observational study, involving persons with multiple sclerosis and healthy controls. The study contains 1 descriptive and 4 experimental sessions. In the descriptive session, participant's clinical motor and cognitive functions are collected. In the first experimental session, participant's beat perception and synchronisation abilities is examined within a finger tapping paradigm. In the following experimental sessions participants synchronsiation abilities is examined during walking paradigms, to music and metronomes, at different tempi and alignment strategies. In the latter three sessions, apart from outcome measures of synchronization the following will be collected as well: spatio-temporal gait parameters, perceived fatigue, perceived motivation and perceived speed of walking.

Papers

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History

    1. Started

      Nov 2020

    2. Main results due

      Jan 2025

    3. Finished

      Feb 2025

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