Cognitive Improvement Through tDCS for Patients With Multiple Sclerosi
Cognitive Improvement Through Transcranial Direct Current Stimulation for Patients With Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Active transcranial direct current stimulation
Placebo
- Sham transcranial direct current stimulation
What it measured
Main measures
Reaction Times in symbol-digit modalities test.
Assessed at two timepoints (1x during active (anodal/cathodal) tDCS intervention at Day 1 or 7 (depends on randomization), 1x during sham tDCS intervention at Day 1 or 7 (depends on randomization))
Other measures (2)
Hit Rate in symbol-digit modalities test.
Assessed at two timepoints (1x during active (anodal/cathodal) tDCS intervention at Day 1 or 7 (depends on randomization), 1x during sham tDCS intervention at Day 1 or 7 (depends on randomization))
Baseline performance in symbol-digit modalities test.
Assessment at baseline (Day 0, before stimulation).
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* diagnosis of multiple sclerosis. * no acute inflammation during the last 3 months before the experimental intervention. * no cortisol treatment during the last 3 months before the experimental intervention. * stable medication during the experimental intervention. * unrestrained or corrected visual ability. * ability to read and write short german sentences. * adequate motor ability to give responses on a keyboard. * German as main language.
Exclusion criteria
* major depressive symptoms or any further neurological and/or psychiatric disease at experimental intervention. * standard tDCS exclusion criteria (e.g. cardiac pacemaker, metal implants in head region, etc.)
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Multiple sclerosis (MS) is a chronic inflammatory disease with around 200.000 patients in Germany. Besides physical symptoms, cognitive resources degrade over the years. Transcranial direct current stimulation (tDCS) is an established procedure to modulate cortical excitability in motor and cognitive functions. Therefore, tDCS may improve cognitive functions in patients with MS. Patients will work on a modified version of the symbol digits modalities test in two experimental sessions. During the task, they will receive either active stimulation or sham stimulation in a crossover design. Active stimulation is divided in anodal and cathodal stimulation. Anodal stimulation should facilitate cognitive processing; cathodal stimulation, on the other hand, should hinder cognitive processing.
Papers
Loading reviews and guidelines…
History
Started
Dec 2020
Main results due
Dec 2023
Finished
Dec 2023