Remediation Program Via a "Serious Game" for the Cognitive Functions o
e-SEP Cognition: Effectiveness of a Remediation Program Via a "Serious Game" on the Cognitive Functions of Multiple Sclerosis Patients: Controlled, Randomized, Multicentric Trial
What it found
No result yet.
What was tested
Treatment tested
- Serious game
Placebo
- Usual HAS care
What it measured
Main measures
Change in the California Verbal Learning Test (CVLT)
Change from baseline at 4 and 10 months
Change in the Brief Visuo-spatial Memory Test (BVMT)
Change from baseline at 4 and 10 months
Thinking and memoryChange in the Symbol Digit Modalities Test (SDMT)
Change from baseline at 4 and 10 months
Thinking and memory
Other measures (20)
Change in the Auditory-verbal spans in direct or reverse order
Change from baseline at 4 and 10 months
Thinking and memoryChange in the Stroop Color-Word Test
Change from baseline at 4 and 10 months
Change in the Trail Making Test
Change from baseline at 4 and 10 months
Thinking and memoryChange in the Categorical and phonemic verbal fluency test
Change from baseline at 4 and 10 months
Change in the Tower of London test
Change from baseline at 4 and 10 months
Change in the Commission test
Change from baseline at 4 and 10 months
Change in the Concentrated Attention Test
Change from baseline at 4 and 10 months
Thinking and memoryChange in the Paced Auditory Serial Addition Task (PASAT)
Change from baseline at 4 and 10 months
Thinking and memoryChange in the Mac Nair Scale
Change from baseline at 4 and 10 months
Thinking and memoryChange in the IPA (Participation and Autonomy Impact) Form
Change from baseline at 4 and 10 months
Mood and sleep
Who could take part
Relapsing and progressive · 18 to 65
Show the full criteria
Inclusion criteria
* Relapsing-remitting or progressive multiple sclerosis people defined according to Mc Donald's criteria revised in 2005 * Age between ≥ 18 and ≤ 65 years old * Cognitive complaint, with at least one deficient score at the initial neuropsychological examination (\<5th percentile of the reference group), one of the scores of which concerns at least one BICAMS test * Have not had a definite relapse for at least 6 weeks * Be at least 4 weeks away from a corticosteroid bolus * Lack of neuroleptic treatment * Patient with an Internet connection * Signed informed consent
Exclusion criteria
* Severe cognitive deficit defined by obtaining a deficit score in more than six cognitive processes at the initial neuropsychological assessment. * Neuropsychological care * Inability to receive oral and written information * Inability to use the software (due in particular to motor and / or sensory difficulties), * Neurological or psychiatric comorbidity, other than MS and anxiodepressive syndrome * Patient with severe anxiodepressive syndrome (BDI> 27) * Participation in an interventional study on cognitive functions * Patient under legal protection, guardianship or curatorship * Pregnant or breastfeeding women
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The main goal of this study is to assess the effectiveness of a cognitive remediation program based on a "serious game" on the information processing speed evolution and the process of learning via episodic memory in multiple sclerosis patients.
Papers
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History
Started
Oct 2021
Main results due
Apr 2026
Finished
Mar 2027