Social Cognition in Multiple Sclerosis, From a Study of Eye Movement a
EYE-SEP : Study of Social Cognition in Patients With Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculography.
What it found
We found no results in the registry or in papers.
This trial finished 7 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Video-oculography / Social cognition tasks / Neuropsychological evaluations
What it measured
Main measures
Prevalence of Oculomotor disorders (OMD)
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Nerve conduction testsEye gaze strategies during Emotion recognition: Affective Theory of Mind (ToM)
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Thinking and memoryNerve conduction testsEye gaze strategies during Emotion recognition assessment: Facial emotion recognition (FER)
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Thinking and memoryNerve conduction tests
Other measures (17)
T2 MRI lesion location: Posterior fossa lesions
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MRI lesionsT2 MRI lesion location: Spinal cord lesions
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MRI lesionsT2 MRI lesion location: T2 lesions load
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MRI lesionsOculomotor paradigms raw performance - Horizontal saccades
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Myelin repairNerve conduction testsOculomotor paradigms raw performance - Vertical saccades
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Myelin repairNerve conduction testsDisease Disability
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Disability progressionDisease Duration
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Correlations between visual exploration strategies and behavioral disorders.
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Thinking and memoryNerve conduction testsCorrelations between visual exploration strategies and social cognition impairment: Facial emotion recognition.
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Thinking and memoryNerve conduction testsCorrelations between visual exploration strategies and social cognition impairment: Affective ToM.
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Thinking and memoryNerve conduction tests
Who could take part
Relapsing and progressive · 18 and over
Show the full criteria
Inclusion criteria
* Male or Female. * 18 years old and above. * Sufficient written and oral expression in French. * Covered by a health insurance system * Written informed consent signed by the patient. * For the MS group: * Patient diagnosed according to diagnostic criteria established by Polman et al. (2010): Radiologically Isolated Syndrome compatible with MS (RIS), Clinically Isolated Syndrome compatible with MS (CIS), Relapsing-Remitting MS, Secondary Progressive MS, or Primary Progressive MS. * Hospitalized or coming to perform a consultation. * For the control group: No cognitive impairment (non pathological Mini-Mental State Examination (MMSE), according to age, gender and socio-cultural level).
Exclusion criteria
* General anaesthesia within 3 months. * Ophthalmological problems preventing a video-oculography examination. * Oculomotor disorders: * For the control group: "fixation disorders" or "ocular tracking disorders". * For the MS group: atypical disorders. * Cognitive disorders of the type: visual agnosia, visuo-spatial disorder, visuo-perceptual disorder or aphasia. * Other neurological or ophthalmological disorders than MS * History of stroke. * Psychotropic drugs consummation.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study aims to: * analyze prospectively the prevalence of subclinical oculomotor disorders (OMDs) in different phenotypes of Multiple Sclerosis (MS) and to study correlations with brain MRI T2 data. * highlight link between modification of visual exploration strategies to decode emotions, and social behavioral disorders, in patients with demyelinating disease, from early to clinically definite stages.
Papers
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History
Started
May 2017
Main results due
Jun 2019
Finished
Jun 2019