ATOMIC (Active Teens Multiple Sclerosis) Physical Activity Research Pr

Physical Activity, Quality of Life and Disease Outcomes in Youth With Multiple Sclerosis: the ATOMIC (Active Teens Multiple Sclerosis) Physical Activity Research Program

Running, not recruitingNot a drug-phase studyEarly (CIS/RIS)NCT04782466

What it found

Still running

No result yet.

What was tested

Treatment tested

  • Physical Activity (PA) Intervention
  • Waitlist attention-control

What it measured

Main measures

  • Physical Activity Level

    Entire study - up to 18 months

    Physical function

Other measures (3)

  • Aerobic Capacity

    Entire study - up to 18 months

    Physical function

  • Self-Reported PA Outcomes

    Entire study - up to 18 months

    Physical function

  • Social Cognitive Theory Based Mediators of Physical Activity

    Entire study - up to 18 months

    Thinking and memoryPhysical function

Who could take part

Early (CIS/RIS) · 11 to 21

Show the full criteria

Inclusion criteria

1. Youth 11-21 years of age; 2. MS diagnosis or clinically isolated syndrome, as per revised McDonald diagnostic criteria and International Pediatric MS Study Group criteria prior to the age of 18; 3. Participating in less than three hours of structured physical activity per week.

Exclusion criteria

1. Have non-specific white matter abnormalities and metabolic or infectious etiologies for white matter abnormalities; 2. Do not speak and read English at a level needed to complete the questionnaires (4th grade level); 3. Have significant motor disability, classified as an Expanded Disability Status Scale (EDSS) ≥4; 4. Are at increased risk of cardiac or other complications of exercise testing (e.g. cardiac disease, diabetes), as determined by the pediatric neurologist or physician.

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

The investigators have previously shown that youth with MS are very inactive, and that vigorous physical activity is associated with higher levels of well-being and lower MS disease activity in youth. Yet, no effective physical activity interventions have been developed for youth with MS to date. The investigators have taken input from youth with MS to create a Smartphone-based app (the ATOMIC - Active Teens with Multiple Sclerosis - App) that provides tailored physical activity information and coaching, provides tools to increase social connectedness, and promotes physical activity. This proposed research will therefore address the problem of inactivity in youth with MS by studying an intervention to increase physical activity.

Papers

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    History

      1. Started

        Dec 2020

      2. Main results due

        Sept 2025

      3. Finished

        Sept 2025

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