Spinal Cord Lesion Detection in Multiple Sclerosis Using Novel MRI Seq

Spinal Cord Lesion Detection in Multiple Sclerosis Using Novel MRI Sequences: A Pilot Study

RecruitingNot a drug-phase studyMS (type not specified)NCT04819737

What it found

Still running

No result yet.

What was tested

Treatment tested

  • SC MRI
  • patient questionnaire

What it measured

Main measures

  • Number of SC lesions

    one time assessment (60 minutes scheduled per patient for the MRI part including preparation time outside of the scanner and actual scanning time)

    MRI lesions

  • Inter-observer agreement on SC lesion count

    one time assessment (60 minutes scheduled per patient for the MRI part including preparation time outside of the scanner and actual scanning time)

    MRI lesions

  • Presence of ongoing inflammation (acute or chronic) in the SC

    one time assessment (60 minutes scheduled per patient for the MRI part including preparation time outside of the scanner and actual scanning time)

    MRI lesions

Who could take part

MS (type not specified) · 18 and over

Show the full criteria

Inclusion criteria

* Diagnosis of multiple sclerosis according to established international criteria * Steroid free period: > 4 weeks * Participation in the Swiss MS Cohort (SMSC) study

Exclusion criteria

* . History of severe (other) neurological, internal or psychiatric disease with SC affection * MRI-related exclusion criteria (questionnaire): 1. Paramagnetic and/or superparamagnetic foreign objects in the body (especially when located close to the SC) 2. Pacemaker 3. Claustrophobia 4. Pregnancy, lactation 5. Known hypersensitivity to gadolinium-based contrast media

As registered. Criteria can change, so ask the trial team or your neurologist.

Contact details on the registry

About this trial

In the sponsor's words

This study is to evaluate the sensitivity and intra-/inter-observer agreement of the averaged magnetization inversion recovery acquisitions (AMIRA) in spinal cord (SC) Multiple sclerosis (MS) lesion detection and to evaluate the additional clinical value of this sequence in clinical settings.

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History

    1. Started

      Jul 2022

    2. Main results due

      Dec 2027

    3. Finished

      Dec 2027

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