Running Title: Walking to Music and in Silence on a Treadmill

The Effect of a 4 Week Auditory-motor Coupling Intervention on Walking, Information Processing Speed and Fatigue in Persons With Multiple Sclerosis: Three Armed Pilot Intervention

CompletedNot a drug-phase studyMS (type not specified)NCT04856345

We could not find results for this trial

What it found

No results found

We found no results in the registry or in papers.

This trial finished 2 years ago. We found no results in the registry or in any paper that cites it.

What was tested

Treatment tested

  • Walking with music with synchronisation

Compared with

  • Walking with music without synchronisation

Placebo

  • walking without music

What it measured

Main measures

  • 12- item multiple sclerosis walking scale

    Baseline

    Walking and mobility

  • 12- item multiple sclerosis walking scale

    week 5

    Walking and mobility

  • 6 minutes walking test to calculate the distance walking Index

    Baseline

    Walking and mobility

  • 6 minutes walking test to calculate the distance walking Index

    week 5

    Walking and mobility

  • 12 minute walking with sensors

    Baseline

    Walking and mobility

  • 12 minute walking with sensors

    week 5

    Walking and mobility

Other measures (26)

  • Paced auditory serial addition test and symbol digit modality test

    Baseline

    Thinking and memory

  • Paced auditory serial addition test and symbol digit modality test

    week 5

    Thinking and memory

  • Motricity Index of dorsi flexors, knee extensors and hip flexors

    Baseline

    Physical function

  • Motricity Index of dorsi flexors, knee extensors and hip flexors

    week 5

    Physical function

  • Modified Aschowrth scale Hamstrings, Tricepts Surae, Quadricepts

    Baseline

    Spasticity

  • Modified Aschowrth scale Hamstrings, Tricepts Surae, Quadricepts

    week 5

    Spasticity

  • Scale for the assessment and rating of ataxia

    Baseline

    Physical function

  • Scale for the assessment and rating of ataxia

    week 5

    Physical function

  • Dynamic gait index

    Baseline

    Walking and mobility

  • Dynamic gait index

    week 5

    Walking and mobility

Who could take part

MS (type not specified) · 18 to 70

Show the full criteria

Inclusion criteria

* A diagnosis of MS if >1, * no relapses >1 month, * ability to walk for 12minutes, * ability to walk independently on a treadmill * walking speed between 0.8-1.2m/s.

Exclusion criteria

* amusia, * deafness, * cognitive impairment hindering understanding of study instructions, * pregnancy.

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

This work is embedded in the context of auditory-motor coupling, which entails the engagement of two systems; the interaction between the music (or repetitive auditory stimuli) and a walking individual (repetitive movements of footfall). In previous studies, the investigators have shown that synchronising steps to beats in music have shown to be feasible in persons with multiple sclerosis, showing increase of step frequency and reduced perceived fatigue[1, 2]. In this current work, The investigators expand previous findings with a pilot intervention study, to investigate if synchronisation is necessary to improve cognitive and motor functions. The proposed experiment includes 30 participants, randomised to three arms of a pilot intervention (10 participants per arm). With the intention of a further case-study analysis, the inestigators request to include 4 additional participants (2 PwMS with cognitive impairment, and 2 persons with cerebellar lesion) to only follow the intervention arm 1.

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History

    1. Started

      Jan 2021

    2. Main results due

      Dec 2023

    3. Finished

      Dec 2023

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