Effect of Variance on Error Correction During Coupling

Understanding the Effect of Variances on Precision in Predictive Coding When Walking to Music and Metronomes in Persons With Multiple Sclerosis With Progressive Subtypes.

CompletedNot a drug-phase studyProgressive MSNCT04856384

What it found

Paper found, not read

A paper reports the results; we have not read it yet. See Papers below.

What was tested

Treatment tested

  • synchronisation abilities

What it measured

Main measures

  • Motricity Index of dorsi flexors, knee extensors and hip flexors

    baseline

    Physical function

  • Modified Aschowrth scale Hamstrings, Tricepts Surae, Quadricepts

    baseline

    Spasticity

  • Scale for the assessment and rating of ataxia

    Baseline

    Physical function

  • Dynamic gait index

    Baseline

    Walking and mobility

  • Time up and Go test

    Baseline

    Walking and mobility

  • 6 minute walking test

    Baseline

    Walking and mobility

  • Brief repeatable battery of Rao

    Baseline

    Thinking and memory

  • Symbol digit mobility test

    Baseline

    Thinking and memoryWalking and mobility

  • Stroop test 0

    Baseline

    Thinking and memory

  • MS walking scale -12

    Baseline

    Walking and mobility

  • Activities-specific balance confidence scale

    Baseline

    Walking and mobility

  • Modified fatigue impact scale

    baseline

    Fatigue

  • Hospital Anxiety and Depression Scale

    Baseline

    Mood and sleep

  • Dual task questionnaire

    Baseline

  • Perceptual tempo and rhythm judgements

    week 1

  • Asynchrony

    week 1

  • 64 channel EEG measurement

    week 1

    Nerve conduction tests

  • Resultant Vector Length

    week 2

  • Resultant Vector Length

    week 3

  • Relative phase angle

    week 2

  • Relative phase angle

    week 3

Other measures (16)

  • Cadencce

    week 2

  • Cadencce

    week 3

  • Stride length

    week 2

  • Stride length

    week 3

  • Speed

    week 2

    Walking and mobility

  • Speed

    week 3

    Walking and mobility

  • Double Support

    week 2

  • Double Support

    week 3

  • Perceived cognitive and physical fatigue

    week 2

    Thinking and memoryFatigueWalking and mobility

  • Perceived cognitive and physical fatigue

    week 3

    Thinking and memoryFatigueWalking and mobility

Who could take part

Progressive MS · 18 to 70

Show the full criteria

Inclusion criteria

* diagnosis of Multiple sclerosis >1 year, diagnosis of progressive MS, * walking speed 0.8-1.2m/s, ability to walk for 6 minutes continuously (canes and rollators are permitted)

Exclusion criteria

* relapse 3 months prior to enrollment, * cognitive impairment impeding understanding of instructions, * beat amusia, * deafness, * pregnancy

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

This study is a case-control study, involving persons with progressive multiple sclerosis and healthy controls. The study contains 1 descriptive and 3 experimental sessions. In the descriptive session, participant's clinical motor and cognitive functions are collected. In the first experimental session, participant's beat perception and synchronisation abilities is examined within a finger tapping paradigm. In the following experimental sessions participants synchronsiation abilities is examined during walking paradigms, to music and metronomes, with period and phase auditory manipulations. In the latter twp sessions, apart from outcome measures of synchronization the following will be collected as well: brain activity using EEG recordings, spatio-temporal gait parameters, perceived fatigue, perceived motivation and perceived speed of walking.

Papers

Loading reviews and guidelines…

History

    1. Started

      Feb 2021

    2. Main results due

      Oct 2024

    3. Finished

      Dec 2024

    Assembled by software from public sources.