3D OPTIMIZED WMN MPRAGE Increased Detection of Focal Spinal Cord Lesio
3D OPTIMIZED WMN MPRAGE Increased Detection of Focal Spinal Cord Lesion in Multiple Sclerosis (WHINUME)
What it found
No result yet.
What was tested
Treatment tested
- 3D OPTIMIZED WMN MPRAGE
What it measured
Main measures
lesions at the cervical level
day 1
MRI lesions
Other measures (9)
lesions at the thoracic level
day 1
MRI lesionssensitivity of the 3D optimised WMN MPRAGE sequence
day 1
MRI lesionspositive predictive value of the 3D optimized WMN MPRAGE sequence
day 1
MRI lesionsIntraclass corelation coefficient
day 1
MRI lesionspathogenicity of the lesions
day 1
MRI lesionspresence of artefacts
day 1
volume of lesion
day 1
MRI lesionscontrast-to-noise ratio
day 1
MRI lesionspatient's disability
day 1
Disability progression
Who could take part
Relapsing and progressive · 18 and over
Show the full criteria
Inclusion criteria
* Patients older than 18 years old * CIS or RRMS * Medullary symptomatology less than 6 months * With or without an objective lesion on a subsequent MRI scan * Signed the Informed Consent
Exclusion criteria
* Pregnant or potentially pregnant women * Breastfeeding woman * Contraindications to MRI * Other diagnosis (Neuro-myelitis spectrum disease or Progressive Multiple Sclerosis) * Surgical history on the spinal cord or lumbar spine * Patient under legal protection
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The aim of this study is to compare the 3D OPTIMIZED MPRAGE WMN sequence to "conventional sequences" used in spinal cord analysis. The patients will be explored at the cervical level with the conventional 2D sagittal T2 FSE, 2D sagittal STIR, 2D sagittal PSIR, 3D T1 MPRAGE sequences, and the sequence of interest 3D sagittal OPTIMIZED WMN MPRAGE and 3D axial OPTIMIZED WMN MPRAGE. At the thoracic level, with the conventional 2D sagittal T2 FSE, 2D sagittal STIR, 3D T1 MPRAGE sequences and the sequence of interest 3D sagittal OPTIMIZED WMN MPRAGE.
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History
Started
Aug 2023
Main results due
May 2026
Finished
May 2026