Function Magnetic Resonance Imaging to Assess Two Therapeutic Strategi
Neurorehabilitation and Functional Recovery in Multiple Sclerosis: Assessing Two Therapeutic Strategies Using Functional Magnetic Resonance Imaging.
We could not find results for this trial
What it found
We found no results in the registry or in papers.
This trial finished 3 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- N-back Cognitive Training
- Virtual Reality Motor and Cognitive Training
What it measured
Main measures
Change from baseline in Correct Responses
Baseline and 10 training days after.
Change from baseline in Reaction Time
Baseline and 10 training days after.
Change from baseline in Omissions
Baseline and 10 training days after.
Change from baseline in Errors
Baseline and 10 training days after.
Change from baseline in Functional Connectivity in resting state
Baseline and 10 training days after.
MRI lesionsNerve conduction testsChange from baseline in Functional Connectivity in task performance
Baseline and 10 training days after.
MRI lesionsNerve conduction testsChange from baseline in SRT-S: Selective Reminding Test (Storing)
Baseline and 10 training days after.
Thinking and memoryChange from baseline in SRT-R: Selective Reminding Test (Retrieval)
Baseline and 10 training days after.
Thinking and memoryChange from baseline in SRT-D: Selective Reminding Test (Delayed)
Baseline and 10 training days after.
Thinking and memoryChange from baseline in SPART: Spatial Recall Test
Baseline and 10 training days after.
Thinking and memoryChange from baseline in SPART-D: Spatial Recall Test (Delayed)
Baseline and 10 training days after.
Thinking and memoryChange from baseline in SDMT: Symbol Digit Modalities Test
Baseline and 10 training days after.
Thinking and memoryChange from baseline in PASAT: Paced Auditory Serial Addition Task
Baseline and 10 training days after.
Thinking and memoryChange from baseline in Phonemic Fluency
Baseline and 10 training days after.
Change from baseline in Semantic Fluency
Baseline and 10 training days after.
Change from baseline in Digit Span Forward
Baseline and 10 training days after.
Thinking and memoryChange from baseline in Digit Span Backward
Baseline and 10 training days after.
Thinking and memoryChange from baseline in Letters and Numbers
Baseline and 10 training days after.
Thinking and memory
Other measures (5)
Total Intracranial Volume (TIV)
Baseline
MRI lesionsBrain volume lossBrain Parenchymal Fraction (BPF)
Baseline
MRI lesionsBrain volume lossLesion Volume in white matter tissue
Baseline
MRI lesionsCortical Lesions
Baseline
MRI lesionsCortical Thickness
Baseline
MRI lesions
Who could take part
MS (type not specified) · 19 to 60
Show the full criteria
Inclusion criteria
* Multiple Sclerosis Diagnosis.
Exclusion criteria
* Other neurological pathologies comorbidity. * Magnetic resonance imaging incompatibilities. * Motor impairment degree that impede the task performance.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Multiple sclerosis (MS) is an autoimmune disease that causes cognitive and motor disabilities and contributes to decrease patients life quality. Previous results described that there are some MS patients that showed (at least in some phases of the disease) neuroplasticity processes that are able to compensate some cognitive deficits. Moreover, neuroplasticity processes seem to be limited and related to the degree of gray matter atrophy (patients with less atrophy show grater neuroplasticity than those with higher atrophy level). The aims of this project are: 1. to study behavioral changes (post-training) induced by two different rehabilitation programs: a)cognitive training focused on exclusively enhancing working memory and b) aerobic + cognitive training aimed to enhance attention, working memory processes and motor capabilities using a virtual reality game. 2. to study neuroplasticity changes (post-training functional connectivity changes) induced by these rehabilitation programs 3. to observe the role of the atrophy in brain neuroplasticity processes. Neuropathological status and neuroplasticity processes (studied using neuroimaging tools) as well as cognitive performance using neuropsychological tools will be assessed in a group of MS patients (with different phenotypes) at two different time points: before any training (S1) and after 10 days of training (S2). This project will be financed by the Ministerio de ciencia, innovación y universidades of the Spanish government and also have been approved by the Ethical committee of Universitat Jaume I.
Papers
Background
Baltruschat SA, Ventura-Campos N, Cruz-Gomez AJ, Belenguer A, Forn C. Gray matter atrophy is associated with functional connectivity reorganization during the Paced Auditory Serial Addition Test (PASAT) execution in Multiple Sclerosis (MS). J Neuroradiol. 2015 Jun;42(3):141-9. doi: 10.1016/j.neurad.2015.02.006. Epub 2015 Apr 6.Background
Cruz-Gomez AJ, Ventura-Campos N, Belenguer A, Avila C, Forn C. The link between resting-state functional connectivity and cognition in MS patients. Mult Scler. 2014 Mar;20(3):338-48. doi: 10.1177/1352458513495584. Epub 2013 Jul 4.Background
Mitolo M, Venneri A, Wilkinson ID, Sharrack B. Cognitive rehabilitation in multiple sclerosis: A systematic review. J Neurol Sci. 2015 Jul 15;354(1-2):1-9. doi: 10.1016/j.jns.2015.05.004. Epub 2015 May 9.Background
Aguirre N, Cruz-Gomez AJ, Esbri SF, Miro-Padilla A, Bueicheku E, Broseta-Torres R, Avila C, Sanchis-Segura C, Forn C. Enhanced frontoparietal connectivity in multiple sclerosis patients and healthy controls in response to an intensive computerized training focused on working memory. Mult Scler Relat Disord. 2021 Jul;52:102976. doi: 10.1016/j.msard.2021.102976. Epub 2021 Apr 24.Background
Sandroff BM, Wylie GR, Sutton BP, Johnson CL, DeLuca J, Motl RW. Treadmill walking exercise training and brain function in multiple sclerosis: Preliminary evidence setting the stage for a network-based approach to rehabilitation. Mult Scler J Exp Transl Clin. 2018 Feb 21;4(1):2055217318760641. doi: 10.1177/2055217318760641. eCollection 2018 Jan-Mar.Background
Aguirre N, Cruz-Gomez AJ, Miro-Padilla A, Bueicheku E, Broseta Torres R, Avila C, Sanchis-Segura C, Forn C. Repeated Working Memory Training Improves Task Performance and Neural Efficiency in Multiple Sclerosis Patients and Healthy Controls. Mult Scler Int. 2019 Apr 16;2019:2657902. doi: 10.1155/2019/2657902. eCollection 2019.
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History
Started
May 2022
Main results due
Jul 2023
Finished
Jul 2023