Multiple Sclerosis and Overactive Bladder Treatment
The Effect of Different Neuromodulation Techniques in the Treatment of Multiple Sclerosis Patients With Neurogenic Bladder Dysfunction
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Transcutaneous Posterior Tibial Nerve Stimulation
Compared with
- Repetitive Transcranial Magnetic Stimulation
What it measured
Main measures
Urodynamics Test
"10 days" the amount of change after 10 days from the baseline
Bladder, bowel and sexual functionExtended Disability Status Scale (EDSS)
"10 days" the amount of change after 10 days from the baseline
Disability progressionBladder, bowel and sexual functionOveractive Bladder Questionnaire-V8 (OAB-V8)
"10 days" the amount of change after 10 days from the baseline
Bladder, bowel and sexual functionIncontinence Quality of Life -I-QOL
"10 days" the amount of change after 10 days from the baseline
Bladder, bowel and sexual functionQuality of life (reported by participants)Voiding Diary
"10 days" the amount of change after 10 days from the baseline
Bladder, bowel and sexual functionIncontinence Severity Index (ISI)
"10 days" the amount of change after 10 days from the baseline
Bladder, bowel and sexual function
Who could take part
MS (type not specified) · 18 to 65
Show the full criteria
Inclusion criteria
* 18-65 years old * Woman * Volunteer to participate in the study * Neurogenic overactive bladder due to MS * EDSS \<7.0 * Not benefiting from pharmacological treatment
Exclusion criteria
* With urinary tract infection * Diagnosed with diabetes mellitus * Using diuretic medication * Using clean intermittent catheterization * Having a history of different urological diseases * Those who have conditions that would be contraindicated for electrical stimulation (pacemaker, brain pacemaker, prosthesis)
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Urinary symptoms are frequently seen in patients with Multiple Sclerosis (MS). Early evaluation of the patients in terms of the urinary system, planning the appropriate treatment and following up at regular intervals are extremely important in terms of preventing urinary system complications. Neuromodulation applications are used reliably in the urological treatment of MS patients. The aim of this study was to compare the efficacy of different neuromodulation techniques, transcutaneous posterior tibial nerve stimulation and repetitive transcranial magnetic stimulation, in patients with MS reporting lower urinary tract symptoms.
Papers
Results
Effect of neuromodulation on neurogenic bladder in women with multiple sclerosis: a pilot randomized controlled trial.Neurodegener Dis Manag · 2025
Results
Atak Cakir P, Mutluay F, Hanoglu L, Guzelburc V. Effect of transcutaneous posterior tibial nerve stimulation and repetitive transcranial magnetic stimulation on neurogenic overactive bladder symptoms in female patients with multiple sclerosis: The study protocol of a randomized controlled study. Front Neurol. 2022 Oct 28;13:1011502. doi: 10.3389/fneur.2022.1011502. eCollection 2022.Background
Nardone R, Versace V, Sebastianelli L, Brigo F, Golaszewski S, Christova M, Saltuari L, Trinka E. Transcranial magnetic stimulation and bladder function: A systematic review. Clin Neurophysiol. 2019 Nov;130(11):2032-2037. doi: 10.1016/j.clinph.2019.08.020. Epub 2019 Sep 3.Background
de Seze M, Raibaut P, Gallien P, Even-Schneider A, Denys P, Bonniaud V, Game X, Amarenco G. Transcutaneous posterior tibial nerve stimulation for treatment of the overactive bladder syndrome in multiple sclerosis: results of a multicenter prospective study. Neurourol Urodyn. 2011 Mar;30(3):306-11. doi: 10.1002/nau.20958. Epub 2011 Feb 8.Background
Abboud H, Hill E, Siddiqui J, Serra A, Walter B. Neuromodulation in multiple sclerosis. Mult Scler. 2017 Nov;23(13):1663-1676. doi: 10.1177/1352458517736150.Background
Fingerman JS, Finkelstein LH. The overactive bladder in multiple sclerosis. J Am Osteopath Assoc. 2000 Mar;100(3 Suppl):S9-12.
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History
Started
Jun 2021
Main results due
Oct 2022
Finished
Dec 2022