Effect of Computerized Cognitive Training in Persons With MS
Effect of Computerized Cognitive Training in Persons With MS
We could not find results for this trial
What it found
We found no results in the registry or in papers.
This trial finished 4 years ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- BrainHQ cognitive training
Compared with
- BrainHQ control games
What it measured
Main measures
Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery
at study completion, approximately 3 months
Thinking and memory
Who could take part
Relapsing MS · 19 to 60 · EDSS 2 to 5.5
Show the full criteria
Inclusion criteria
* Ages 19-60 inclusive * Expanded Disability Status Scale (EDSS) score of 2-5.5 inclusive * Relapsing-Remitting MS according to McDonald Criteria * 17 or above on the Montreal Cognitive Assessment (MoCA) * 70 or above on the Test of Premorbid Functioning (TOPF) * 29 or less on the Beck Depression Inventory (BDI-II) * Less than 15 on the Generalized Anxiety Disorder (GAD-7)
Exclusion criteria
* Relapse within the last 6 months * Disease modifying treatment (DMT) change within the last 6 months * Primary Progressive MS or Secondary Progressive MS according to McDonald Criteria * No access to computer/internet * Currently undergoing treatment for cognitive impairment * Answers a 2 or 3 on the suicidal thoughts question of the BDI-II * Answers a 1 on the suicidal thoughts question of the BDI-II and then a Columbia Suicide Severity Rating Scale indicates more than low risk
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Multiple sclerosis (MS) affects approximately one million people in the United States and 2.5 million worldwide. Between one million and 1.75 million persons with MS (PwMS) worldwide are estimated to suffer from cognitive impairment. Unfortunately, there is currently no consensus on the best treatment for cognitive impairment in PwMS. The objective for this study is to determine if a computerized cognitive training using the BrainHQ platform can improve cognitive impairment in PwMS. The central hypothesis is that computerized cognitive training will show some improvement in cognitive impairment. The rationale for this study is to treat all aspects of MS, not just the physical symptoms and to help PwMS live their best life. Cognitive impairment is associated with higher rates of depression in PwMS and depression leads to medication non-adherence. This means the cognitive impairment so many PwMS are dealing with must be treated. Finding non-pharmacological interventions to mitigate cognitive declines are essential to ensure that quality of life for PwMS patients matches our ability to treat and mitigate their physical symptoms of MS. To obtain the overall objectives for this study the following specific aim will be pursued: Determine the effectiveness of computerized cognitive training on changes in cognitive impairment for PwMS. This will be accomplished by completing a randomized clinical trial with two groups: computerized cognitive training using BrainHQ and an active control group that will complete non-cognitive training programs on BrainHQ. Subjects will complete the BICAMS battery at baseline and at the end of their six week intervention. Subjects will be prescribed online activities through BrainHQ to complete 2-3 times a week for approximately 20-30 minutes each. Subjects will also be asked to wear an accelerometer for a week to determine if physical activity affects cognition. The proposed research is significant because MS is diagnosed on average at age 30, meaning a high percentage of the PwMS that are suffering with cognitive impairment are in their second, third and fourth decade when they are trying to raise a family, finish college, further their career and have active social lives.
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History
Started
Jun 2022
Main results due
Oct 2022
Finished
Oct 2022