Cognitive-motor Telerehabilitation in MS
Cognitive-motor Telerehabilitation in Multiple Sclerosis
What it found
No result yet.
What was tested
Treatment tested
- Cognitive training
- Motor training
What it measured
Main measures
Change in Digit span backwards
0 weeks, 12 weeks, 24 weeks, 64 weeks
Thinking and memory
Other measures (14)
Change in Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS)
0 weeks, 12 weeks, 24 weeks, 64 weeks
Thinking and memoryChange in Corsi backwards
0 weeks, 12 weeks, 24 weeks, 64 weeks
Thinking and memoryChange in Expanded Disability Status Scale (EDSS)
0 weeks, 12 weeks, 24 weeks, 64 weeks
Disability progressionChange in 6-Minute Walk Test (6MWT)
0 weeks, 12 weeks, 24 weeks, 64 weeks
Walking and mobilityChange in 25-Foot Walk Test (25FWT)
0 weeks, 12 weeks, 24 weeks, 64 weeks
Walking and mobilityChange in 9-Hole Peg Test (9HPT)
0 weeks, 12 weeks, 24 weeks, 64 weeks
Disability progressionArm and hand functionMRI T1 3D BRAVO scan
0 weeks, 12 weeks, 24 weeks
MRI lesionsMRI T2 FLAIR 3D Cube scan
0 weeks, 12 weeks, 24 weeks
MRI lesionsDiffusion weighted image (DWI)
0 weeks, 12 weeks, 24 weeks
MRI lesionsNerve conduction testsSynthetic MRI
0 weeks, 12 weeks, 24 weeks
MRI lesions
Who could take part
MS (type not specified) · 18 to 65
Show the full criteria
Inclusion criteria
* Clinically definite multiple sclerosis (revised McDonald criteria 2017) * Expanded Disability Status Scale (EDSS) below 6.0 * Digit span backwards z-score between [-3 and -0.5] standard deviations below the median of the normative values * Age between 18 and 65 * Able to safely perform motor rehabilitation in the home situation (assessed by rehabilitation physician and/or occupational or physiotherapist)
Exclusion criteria
* Cognitive rehabilitation within six months before inclusion * Inpatient multidisciplinary rehabilitation program within three months before inclusion or planned inpatient program during trial * Start of or switch in immunomodulator treatment within three months before inclusion * Less than one month post-exacerbation * Major psychiatric or medical disorder that could influence cognitive functions * Combined vision with optimal correction below 0.6 on Snellen Visual Acuity Test * Unable or unwilling to undergo EEG or MRI * Refusing informed consent
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The primary goal of this project is providing evidence that a home-based combined cognitive-motor training program improves cognition in persons with multiple sclerosis (MS), compared to single cognitive and motor rehabilitation. Secondary goals are to assess the effects on walking performance and to identify the mechanisms of improvement and predictors of treatment response. The main backbone of this project will be a randomized controlled two-centre clinical trial, in which an at-home computerised cognitive-motor rehabilitation program using telemedicine aimed at improving working memory in persons with MS will be evaluated. Based on the information gathered during this trial, possible mechanisms of improvement will be identified by analysing anatomical and neurophysiological changes on structural MRI and resting-state and task-related EEG before and after rehabilitation. Furthermore, factors that can predict treatment response to the rehabilitation program will be identified.
Papers
Loading reviews and guidelines…
History
Started
Sept 2022
Main results due
Aug 2027
Finished
Aug 2027