Fatigability in Persons With Multiple Sclerosis: Inputs From Cognition
Walking-related Fatigability in Persons With Multiple Sclerosis: Psychometric Properties of Cognitive and Coordination Fatigability Assessment & Proof-of-concept of a Rehabilitation Intervention
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Dance therapy
Given to everyone in the trial
- Psychometric properties (Validity, Reliability) of interlimb coordination- and cognitive-fatigability
What it measured
Main measures
The phase coordination index (PCI)
baselline
The phase coordination index (PCI)
Day 7
The phase coordination index (PCI)
week 8
Movement Amplitude- Chair Coordination test
Baseline
Movement Amplitude- Chair Coordination test
Day 7
Movement Amplitude- Chair Coordination test
Week 8
Movement Frequency- Chair Coordination test
Baseline
Movement Frequency- Chair Coordination test
Day 7
Movement Frequency- Chair Coordination test
week 8
Workload- Chair Coordination test
Baseline
Workload- Chair Coordination test
Day 7
Workload- Chair Coordination test
week 8
Motor fatigability during the 6 minutes condition
Baseline
Walking and mobilityMotor fatigability during the 6 minutes condition
Day 7
Walking and mobilityMotor fatigability during the 6 minutes condition
week 8
Walking and mobilitythe paced auditory serial addition test (PASAT)
Baseline
Thinking and memorythe paced auditory serial addition test (PASAT)
Day 7
Thinking and memorythe paced auditory serial addition test (PASAT)
week 8
Thinking and memorythe symbol digit modality test (SDMT)
Baseline
Thinking and memorythe symbol digit modality test (SDMT)
Day 7
Thinking and memorythe symbol digit modality test (SDMT)
week 8
Thinking and memoryThe 6 minute walking test
baseline
Walking and mobilityThe 6 minute walking test
Day 7
Walking and mobilityThe 6 minute walking test
week 8
Walking and mobility
Other measures (39)
Spatiotemporal gait parameter- Cadence
Baseline
Disability progressionWalking and mobilitySpatiotemporal gait parameter- Cadence
day 7
Disability progressionWalking and mobilitySpatiotemporal gait parameter- Cadence
week 8
Disability progressionWalking and mobilitySpatiotemporal gait parameter- Stride length
Baseline
Disability progressionWalking and mobilitySpatiotemporal gait parameter- Stride length
Day 7
Disability progressionWalking and mobilitySpatiotemporal gait parameter- Stride length
week 8
Disability progressionWalking and mobilitySpatiotemporal gait parameter- Gait speed
Baseline
Disability progressionWalking and mobilitySpatiotemporal gait parameter- Gait speed
Day 7
Disability progressionWalking and mobilitySpatiotemporal gait parameter- Gait speed
week 8
Disability progressionWalking and mobilitySpatiotemporal gait parameter- Double support
Baseline
Disability progressionWalking and mobility
Who could take part
MS (type not specified) · 30 to 70
Show the full criteria
Inclusion criteria
* Persons with MS presenting walking-related fatigability (Distance walk index ≤-10); * age between 30 and 70 years old; * a diagnosis of MS (2017 revisions of the McDonalds criteria) with Expanded Disability Status Scale (EDSS) 4 up to 6.5. * no relapses >1 month preceding the start of the study * ability to walk for 6 minutes without rest.
Exclusion criteria
* Cognitive impairment hindering understanding of study instructions, * pregnancy * musculoskeletal disorders in the lower limbs not related to MS.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Walking impairments occur in 93% of persons with MS (pwMS) within 10 years of diagnosis. Besides the impact of muscle weakness or hypertonia, one is increasingly aware about the symptom of fatigability. Motor and cognitive fatigability is a change in performance over time depending on the tasks and circumstances. It was shown that up to half of disabled pwMS slow down during walking, impacting on real life mobility. Walking function is related to functional muscle strength, balance and centrally mediated coordination deficits but also cognitive function. Preliminary data conducted by our research group has shown that people with MS with walking fatigability had a significant decrease in movement amplitude during a bipedal coordination task in sitting position. However, the psychometric properties such as within-session and test-retest reliability of bipedal function has not yet been determined. In addition, so far, no interventional research has included exclusively people with MS with walking-related fatigability. It is unknown if the downward curve in walking speed and coordination can be reversed by multi-model interventions. The study will have two parts (A and B). Part A investigates psychometric properties of outcome measures related to fatigability in healthy controls, persons with MS with and without fatigability during walking. Part B is an intervention study in persons with MS and fatigability, comparing dance with a sham intervention, and its effects primarily on fatigability outcomes.
Papers
Loading reviews and guidelines…
History
Started
Sept 2021
Main results due
Mar 2023
Finished
May 2024