Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pont
Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pontine Lesion: a Pilot Study
What it found
No result yet.
What was tested
Treatment tested
- Deep brain stimulation
What it measured
Main measures
Demonstrating the feasibility of the intervention by assessing protocol completion without deviation
24 months
SafetyFeasibility
Other measures (7)
Lead implantation accuracy
24 months
Pain evolution
24 months
PainFacial numbness
24 months
Complications
24 months
SafetyQuality of life progression
24 months
PainQuality of life (reported by participants)Patient acceptability of the procedure
24 months
FeasibilityPatient global impression of change
24 months
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* Adults of at least 18 years old * Refractory trigeminal neuralgia : failure of at least 3 drugs and at least two lesioning surgical interventions (radiosurgery, percutaneous rhizotomy, or open rhizotomy). * Pontine lesion proved by MRI in contact with trigeminal nerve tract
Exclusion criteria
* Absolute contraindication to MRI * Medical contraindication to the procedure
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The aim of this study is to assess the feasibility of deep brain stimulation for refractory trigeminal neuralgia due to a pontine lesion, as is usually seen in the context of multiple sclerosis. These patients usually have severe intractable facial pain and current medical and surgical options generally fail to achieve long lasting pain relief. Hoping to improve pain control in this population, the investigators of this trial propose a novel technique consisting of implanting a deep brain stimulation lead within the pontine lesion to modulate the generation of pain signals.
Papers
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History
Started
Oct 2024
Main results due
Oct 2025
Finished
Oct 2026