Effect of Tai Chi on Balance, Mood, Cognition, and Quality of Life in
The Combined Impact of a Structured Tai Chi Exercise Program on Selected Clinical Aspects and Quality of Life of Patients With Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- "Tai-chi" - a special program for patients with multiple sclerosis - once a week training with a Tai Chi instructor lasting 90 minutes
What it measured
Main measures
V0 visit- Static posturography
1. day
V1 visit- Static posturography
3 months after V0 visit
V2 visit- Static posturography
6 months after V0 visit
V3 visit- Static posturography
9 months after V0 visit
V4 visit- Static posturography
12 months after V0 visit
V0 visit- Static posturography LI
1. day
V1 visit- Static posturography LI
3 months after V0 visit
V2 visit- Static posturography LI
6 months after V0 visit
V3 visit- Static posturography LI
9 months after V0 visit
V4 visit- Static posturography LI
12 months after V0 visit
V0 visit- Static posturography TA
1. day
V1 visit- Static posturography TA
3 months after V0 visit
V2 visit- Static posturography TA
6 months after V0 visit
V3 visit- Static posturography TA
9 months after V0 visit
V4 visit- Static posturography TA
12 months after V0 visit
V0 visit- Static posturography RMS
1. day
V1 visit- Static posturography RMS
3 months after V0 visit
V2 visit- Static posturography RMS
6 months after V0 visit
V3 visit- Static posturography RMS
9 months after V0 visit
V4 visit- Static posturography RMS
12 months after V0 visit
V0 visit- Mini-BESTest
1. day
Walking and mobilityV1 visit- Mini-BESTest
3 months after V0 visit
Walking and mobilityV2 visit- Mini-BESTest
6 months after V0 visit
Walking and mobilityV3 visit- Mini-BESTest
9 months after V0 visit
Walking and mobilityV4 visit- Mini-BESTest
12 months after V0 visit
Walking and mobility
Other measures (50)
V0 visit- EDSS - Expanded disability status scale
1. day
Disability progressionV1 visit- EDSS - Expanded disability status scale
3 months after V0 visit
Disability progressionV2 visit- EDSS - Expanded disability status scale
6 months after V0 visit
Disability progressionV3 visit- EDSS - Expanded disability status scale
9 months after V0 visit
Disability progressionV4 visit- EDSS - Expanded disability status scale
12 months after V0 visit
Disability progressionV0 visit- T25FW - Timed 25-foot walk test
1. day
Disability progressionWalking and mobilityV1 visit- T25FW - Timed 25-foot walk test
3 months after V0 visit
Disability progressionWalking and mobilityV2 visit- T25FW - Timed 25-foot walk test
6 months after V0 visit
Disability progressionWalking and mobilityV3 visit- T25FW - Timed 25-foot walk test
9 months after V0 visit
Disability progressionWalking and mobilityV4 visit- T25FW - Timed 25-foot walk test
12 months after V0 visit
Disability progressionWalking and mobility
Who could take part
MS (type not specified) · 20 to 60
Show the full criteria
Inclusion criteria
1. clinically defined MS, 2. age from 20 to 60 years, 3. and the ability to stand and walk independently at least 200 meters without an assistive device.
Exclusion criteria
1. clinical MS exacerbation during the study, 2. disease-modifying drug change during the study, 3. pregnancy, 4. involvement in any other exercise programme, 5. severe cognitive deficit (defined by Montreal Cognitive Assessment score ≤19), and 6. any other health condition that would interfere with an exercise programme (such as musculoskeletal disorder, lung, or heart disease).
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS). The clinical picture is very variable, ultimately resulting in disability. Disease attacks manifest themselves depending on the location of the CNS damaged by inflammation, demyelination, axonal loss and gliosis. The most common manifestations include motor disorders with the development of stiffness, balance and coordination, cognition, fatigue and depression. In the long term, most patients with MS will achieve significant and irreversible incapacitation. Immunomodulatory therapy is designed to reduce disease activity, slowing progression, but only to a certain extent. A significant benefit, but little researched, is physical exercise. Tai Chi has a positive effect on various neurological diseases. In recent studies, Tai Chi has shown improvements in coordination and balance, depression, anxiety, cognition and overall quality of life in patients with MS. The aim of the project is to assess the therapeutic value of structured Tai Chi exercise based on published clinical work.
Papers
Results
Gibson JC, Summers GD. Bone health in multiple sclerosis. Osteoporos Int. 2011 Dec;22(12):2935-49. doi: 10.1007/s00198-011-1644-8. Epub 2011 May 21.Results
Arnett PA, Strober LB. Cognitive and neurobehavioral features in multiple sclerosis. Expert Rev Neurother. 2011 Mar;11(3):411-24. doi: 10.1586/ern.11.12.Results
Latimer-Cheung AE, Pilutti LA, Hicks AL, Martin Ginis KA, Fenuta AM, MacKibbon KA, Motl RW. Effects of exercise training on fitness, mobility, fatigue, and health-related quality of life among adults with multiple sclerosis: a systematic review to inform guideline development. Arch Phys Med Rehabil. 2013 Sep;94(9):1800-1828.e3. doi: 10.1016/j.apmr.2013.04.020. Epub 2013 May 10.Results
Alvarenga-Filho H, Sacramento PM, Ferreira TB, Hygino J, Abreu JEC, Carvalho SR, Wing AC, Alvarenga RMP, Bento CAM. Combined exercise training reduces fatigue and modulates the cytokine profile of T-cells from multiple sclerosis patients in response to neuromediators. J Neuroimmunol. 2016 Apr 15;293:91-99. doi: 10.1016/j.jneuroim.2016.02.014. Epub 2016 Feb 26.Results
Wens I, Keytsman C, Deckx N, Cools N, Dalgas U, Eijnde BO. Brain derived neurotrophic factor in multiple sclerosis: effect of 24 weeks endurance and resistance training. Eur J Neurol. 2016 Jun;23(6):1028-35. doi: 10.1111/ene.12976. Epub 2016 Mar 16.Results
Husted C, Pham L, Hekking A, Niederman R. Improving quality of life for people with chronic conditions: the example of t'ai chi and multiple sclerosis. Altern Ther Health Med. 1999 Sep;5(5):70-4.Results
Azimzadeh E, Hosseini MA, Nourozi K, Davidson PM. Effect of Tai Chi Chuan on balance in women with multiple sclerosis. Complement Ther Clin Pract. 2015 Feb;21(1):57-60. doi: 10.1016/j.ctcp.2014.09.002. Epub 2014 Nov 27.Results
Burschka JM, Keune PM, Oy UH, Oschmann P, Kuhn P. Mindfulness-based interventions in multiple sclerosis: beneficial effects of Tai Chi on balance, coordination, fatigue and depression. BMC Neurol. 2014 Aug 23;14:165. doi: 10.1186/s12883-014-0165-4.Results
Menkyova I, Stastna D, Novotna K, Saling M, Lisa I, Vesely T, Slezakova D, Valkovic P. Effect of Tai-chi on balance, mood, cognition, and quality of life in women with multiple sclerosis: A one-year prospective study. Explore (NY). 2024 Mar-Apr;20(2):188-195. doi: 10.1016/j.explore.2023.07.011. Epub 2023 Aug 6.
Loading reviews and guidelines…
History
Started
Jan 2019
Main results due
Jan 2020
Finished
Jan 2022