Reducing Fatigue in People With Multiple Sclerosis by Treatment With T
Reducing Fatigue in People With Multiple Sclerosis by Treatment With Transcutaneous Electrical Nerve Stimulation
What it found
No result yet.
What was tested
Treatment tested
- Transcutaneous electrical nerve stimulation
What it measured
Main measures
Fatigue
Changes at Weeks 4, 7, and 11
FatigueWalking limitations
Changes at Weeks 4, 7, and 11
Walking and mobilityWalking endurance
Changes at Weeks 4, 7, and 11
Walking and mobilityMobility
Changes at Weeks 4, 7, and 11
Walking and mobility
Other measures (2)
Quality of life questionnaire
Changes at Weeks 4, 7, and 11
Quality of life (reported by participants)Muscle strength
Changes at Weeks 4, 7, and 11
Physical function
Who could take part
Relapsing MS · 18 to 65
Show the full criteria
Inclusion criteria
* Men and women18-65 yrs * Able to read, understand, and speak English to ensure safe participation in the project * Clinical diagnosis of relapsing-remitting MS * Self-reported difficulty with walking * On stable doses of Ampyra, provigil, or other symptomatic-treating medications * No relapse or systemic steroids within the last 30 days * Able to arrange transportation to the Boulder campus
Exclusion criteria
* Vision or hearing problems that have not been corrected * Problems with sensations to temperature, pressure, or pain * Any arm or leg problems that would influence the ability to hold a weight * Surgery to the arms or legs that continues to bother the participant * Metal implants * Medical diagnosis or condition that is considered to be an absolute or relative contraindication to participating in exercise training, such as major renal, pulmonary, hepatic, cardiac, gastrointestinal, HIV, cancer (other than treated basal cell cancer), other neurological disorders, or pregnancy * History of head injury or stroke * Taking antidepressants, anticholinergics, stimulants, sedatives, cannabis, illicit drugs or medications to treat herpes or neurologic pain. * Diagnosis of diabetes mellitus * Poorly controlled hypertension * History of seizure disorders * ≥2 alcoholic drinks/day, or present history (last 6 months) of drug abuse * Spasticity that requires the individual to change intended activities more often than once a week * Skin diseases or sensation problems in the legs or hands that influences some activities more often than once a week * Inability to attend exercise sessions 3 days per week for 6 weeks
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The objective of the randomized, sham-controlled trial will be to evaluate the effectiveness of treatment with transcutaneous electrical nerve stimulation (TENS) at reducing the level of fatigue experienced by people with MS.
Papers
Results
Almuklass AM, Davis L, Hamilton LD, Hebert JR, Alvarez E, Enoka RM. Pulse Width Does Not Influence the Gains Achieved With Neuromuscular Electrical Stimulation in People With Multiple Sclerosis: Double-Blind, Randomized Trial. Neurorehabil Neural Repair. 2018 Jan;32(1):84-93. doi: 10.1177/1545968317753681. Epub 2018 Jan 24.Results
Almuklass AM, Capobianco RA, Feeney DF, Alvarez E, Enoka RM. Sensory nerve stimulation causes an immediate improvement in motor function of persons with multiple sclerosis: A pilot study. Mult Scler Relat Disord. 2020 Feb;38:101508. doi: 10.1016/j.msard.2019.101508. Epub 2019 Nov 6.Results
Alenazy M, Daneshgar Asl S, Petrigna L, Feka K, Alvarez E, Almuklass AM, Enoka RM. Treatment with electrical stimulation of sensory nerves improves motor function and disability status in persons with multiple sclerosis: A pilot study. J Electromyogr Kinesiol. 2021 Dec;61:102607. doi: 10.1016/j.jelekin.2021.102607. Epub 2021 Oct 13.Background
Enoka RM, Almuklass AM, Alenazy M, Alvarez E, Duchateau J. Distinguishing between Fatigue and Fatigability in Multiple Sclerosis. Neurorehabil Neural Repair. 2021 Nov;35(11):960-973. doi: 10.1177/15459683211046257. Epub 2021 Sep 28.
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History
Started
Apr 2023
Main results due
May 2027
Finished
Nov 2028