Sunlight-mediated Inter-organ Leukocyte Exchange
Sunlight-mediated Inter-organ Leukocyte Exchange
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- 311 nm narrowband UVB irradiation
What it measured
Main measures
Vitamin D3 serum concentration (ng/mL)
4 weeks
How the body handles the medicine
Other measures (1)
single-cell RNA sequencing
1 year
Blood or spinal fluid markersImmune response
Who could take part
Relapsing MS · 18 to 60
Show the full criteria
Inclusion criteria
* RRMS according to revised McDonald criteria (2017) or healthy volunteer * Patients under treatment of natalizumab, teriflunomide, glatirameracetat or dimethyl fumarate for at least 4 weeks of therapy, or therapy-naïve patients will be included
Exclusion criteria
* Patients receiving treatment in the last 3 months of interferon-β, fingolimod, alemtuzumab, ocrelizumab, cladribine, ofatumumab, ozanimod, or ponesimod * Vitamin D supplementation in the last 8 weeks * UVB-narrowband contraindicated skin diseases (e.g., cutaneous neoplasia) * Lacking the ability to stand on their own in the treatment chamber * Signs of intolerance regarding UVB radiation * Intake of UV-sensitive therapeutics * Further autoimmune diseases (e.g., Morbus Crohn, psoriasis, neurodermatitis) * Additional recreational or therapeutic UV radiation (e.g., solarium)
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Ultraviolet B (UVB) irradiation induces regulatory immune cell types that may transmigrate from the skin to the blood and to the central nervous system and exert regulatory effects. Vitamin D deficiency-associated gene variants should reduce this effect if this is mediated by vitamin D. For this study, participants will be irradiated with UVB for 4 weeks. Single cell RNA Sequencing will be performed on isolated immune cells from skin, blood and Cerebrospinal fluid (CSF), before and after irradiation.
Papers
Results
Single-cell analysis of skin and blood reveals systemic immune responses to ultraviolet B and their impairment in MS.J Neuroinflammation · 2026
Loading reviews and guidelines…
History
Started
Nov 2022
Main results due
Apr 2023
Finished
Apr 2023