Cardiovascular Fitness of Patients With Multiple Sclerosis, Effect of
Cardiovascular Fitness and the Influence of a Controlled Combined Exercise Program on Fatigue and Depression of Newly Diagnosed Patients With Multiple Sclerosis
We could not find results for this trial
What it found
We found no results in the registry or in papers.
What was tested
Treatment tested
- Controlled combined exercise group
Compared with
- Conventional rehabilitation
What it measured
Main measures
Maximal aerobic capacity (VO2max.kg-1)
6 months
Physical functionPower to weight ratio (W.kg-1)
6 months
Other measures (7)
Modified Fatigue Impact Scale (MFIS)
6 months
FatigueSymptom-Checklist-90-Standard (SCL-90-S)
6 months
Beck Depression Inventory Score II (BDI II)
6 months
Mood and sleep36-Item Short Form Survey (SF-36)
6 months
Quality of life (reported by participants)Maximal heart rate (bpm)
6 months
Heart rate variability (ms)
6 months
Body composition analysis %)
6 months
Physical function
Who could take part
Relapsing MS · 20 to 45 · EDSS 0 to 6
Show the full criteria
Inclusion criteria
* Age 20 - 45 years * Newly diagnosed patients with multiple sclerosis * Relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS) * EDSS 0-6 * Signed informed consent
Exclusion criteria
* Progressive forms of MS (PRMS or SPMS), Malignant MS * Non-cooperation, disagreement with the study * Contraindication to spiroergometry
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
This study is focused on patients with multiple sclerosis (MS), their cardiovascular fitness, and the effect of combined controlled training on the perception of fatigue, the development of depression, and quality of life in the first year after diagnosis.
Papers
Background
Razazian N, Kazeminia M, Moayedi H, Daneshkhah A, Shohaimi S, Mohammadi M, Jalali R, Salari N. The impact of physical exercise on the fatigue symptoms in patients with multiple sclerosis: a systematic review and meta-analysis. BMC Neurol. 2020 Mar 13;20(1):93. doi: 10.1186/s12883-020-01654-y.Background
Taul-Madsen L, Connolly L, Dennett R, Freeman J, Dalgas U, Hvid LG. Is Aerobic or Resistance Training the Most Effective Exercise Modality for Improving Lower Extremity Physical Function and Perceived Fatigue in People With Multiple Sclerosis? A Systematic Review and Meta-analysis. Arch Phys Med Rehabil. 2021 Oct;102(10):2032-2048. doi: 10.1016/j.apmr.2021.03.026. Epub 2021 Apr 24.Background
Cruickshank TM, Reyes AR, Ziman MR. A systematic review and meta-analysis of strength training in individuals with multiple sclerosis or Parkinson disease. Medicine (Baltimore). 2015 Jan;94(4):e411. doi: 10.1097/MD.0000000000000411.Background
Hansen D, Wens I, Keytsman C, Eijnde BO, Dendale P. Is long-term exercise intervention effective to improve cardiac autonomic control during exercise in subjects with multiple sclerosis? A randomized controlled trial. Eur J Phys Rehabil Med. 2015 Apr;51(2):223-31. Epub 2014 Mar 6.
Loading reviews and guidelines…
History
Started
May 2022
Main results due
Jun 2025
Finished
Dec 2025