A Closed Loop, Doctor to Patient, Mobile Application for Depression in
Care Technology to Ascertain, Treat, and Engage the Community to Heal Depression in Patients With Multiple Sclerosis: Closing the Gaps in Depression Care for People With MS By Closing the Information Loop
What it found
No result yet.
What was tested
Treatment tested
- MS CATCH
What it measured
Main measures
Mood Screening - Primary
0-6 months, 0-12 months
Mood and sleepMood Reporting - Secondary
6 months, Baseline, 12 months
Mood and sleepComprehensive Mood Evaluation - Secondary
0-6 months, 0-12 months
Mood and sleepTreatment recommendations - Secondary
0-6 months, 0-12 months
Treatment recommendation follow-through - Secondary
0-6 months, 0-12 months
Adoption (uptake) - Primary
Initial month
Adoption (uptake) - Secondary
Baseline, 6 months
Other measures (13)
Mood scores - Primary
Baseline, 3, 6, 9, and 12 months
Mood and sleepMood scores - Exploratory
12 months
Mood and sleepMood scores - Exploratory
0-12 months, 0-6 months, 6-12 months
Mood and sleepOther self-reported outcome - Modified Fatigue Impact Scale - Exploratory
0-12 months, 0-6 months, 6-12 months
FatigueMood and sleepOther self-reported outcome - Pittsburgh Sleep Quality Index - Exploratory
0-12 months, 0-6 months, 6-12 months
Mood and sleepOther self-reported outcome - Oxford-Participation and Activities Questionnaire - Exploratory
0-12 months, 0-6 months, 6-12 months
Mood and sleepOther self-reported outcome - Impact on Participation and Autonomy - Exploratory
0-12 months, 0-6 months, 6-12 months
Mood and sleepEngagment (Sustained use) - Secondary
Every 3 months
Engagement (Sustained use) - Secondary
12 months
Engagement (Sustained use) - Exploratory
Baseline, 6 month, 12 month
Who could take part
MS (type not specified) · 18 to 80
Show the full criteria
Inclusion criteria
* Diagnosis of MS (relapsing or progressive) by 2017 McDonald Criteria18 * Ages 18 to 80 * PHQ-9 score of 5-19 * Any MS therapy, or no treatment * California resident to enable clinical telemedicine visits if warranted during the study visit
Exclusion criteria
* Cognitive dexterity or visual impairment (typically defined as corrected acuity less than 20/70) that, in the opinion of the study neurologist (RB), would put the participant at risk or limit their ability to adhere to the study protocol * Inability to provide informed consent * Psychotic disorders: bipolar disorder, schizophrenia, schizoaffective disorder * Substance abuse that in the treating neurologist's perspective could influence the patient's safety on study or adherence to study protocol * Another co-morbid CNS diagnosis eg. TBI
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The researchers want to find out if an electronic application called MS CATCH can enhance patients' and doctors' experiences during and in between clinical visits. MS CATCH is a smartphone-based tool which allows patients to enter their mood related symptoms at regular intervals, which is then available to their Neurologist in their electronic medical record. The neurologist is also able to view additional information from their medical record, and receives alerts for changes reported by the patient that raise concern for the patient's mental health.
Papers
Results
Pragmatic phase II clinical trial to improve depression care in a real-world diverse MS cohort from an academic MS centre in Northern California: MS CATCH study protocol.BMJ Open · 2024
Results
Henderson K, Reihm J, Koshal K, Wijangco J, Sara N, Miller N, Doyle M, Mallory A, Sheridan J, Guo CY, Oommen L, Rankin KP, Sanders S, Feinstein A, Mangurian C, Bove R. A Closed-Loop Digital Health Tool to Improve Depression Care in Multiple Sclerosis: Iterative Design and Cross-Sectional Pilot Randomized Controlled Trial and its Impact on Depression Care. JMIR Form Res. 2024 Mar 15;8:e52809. doi:
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History
Started
Aug 2023
Main results due
Jan 2027
Finished
Jan 2027