Effect of High Intensity Interval Training in Patients With Multiple S
Effect of High Intensity Interval Training in Patients With Multiple Sclerosis: Systematic Review
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- high intensity interval training
What it measured
Main measures
cognitive function
8-12 weeks or less
Thinking and memory
Other measures (1)
mental processing speed
8-12 weeks or less
Thinking and memory
Who could take part
MS (type not specified) · 20 to 50
Show the full criteria
Inclusion criteria
* Studies: English full texts of RCTs only, Participants: multiple sclerosis patients with age from (20-50) years old irrespectively of sex, subtype of MS, race, diagnostic criteria, community or onset of the disease, Intervention: HIIT, any comparator.
Exclusion criteria
* Studies other than English full text RCTs, non adults younger than 20 years and older than 50 years, populations other than multiple sclerosis.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
In this study, we are aiming to systematically review the literature on the effect of HIIT on MS patients as improving physical performance, cognitive function, aerobic fitness and muscle strength. This could help guide the development of standardized clinical guidelines and direct clinical decision making by the physical therapists whether to implement this type of exercises or not.
Papers
Results
Zimmer P, Bloch W, Schenk A, Oberste M, Riedel S, Kool J, Langdon D, Dalgas U, Kesselring J, Bansi J. High-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial. Mult Scler. 2018 Oct;24(12):1635-1644. doi: 10.1177/1352458517728342. Epub 2017 Aug 21.Results
Langeskov-Christensen M, Grondahl Hvid L, Nygaard MKE, Ringgaard S, Jensen HB, Nielsen HH, Petersen T, Stenager E, Eskildsen SF, Dalgas U. Efficacy of High-Intensity Aerobic Exercise on Brain MRI Measures in Multiple Sclerosis. Neurology. 2021 Jan 12;96(2):e203-e213. doi: 10.1212/WNL.0000000000011241. Epub 2020 Dec 1.Results
Spaas J, Goulding RP, Keytsman C, Fonteyn L, van Horssen J, Jaspers RT, Eijnde BO, Wust RCI. Altered muscle oxidative phenotype impairs exercise tolerance but does not improve after exercise training in multiple sclerosis. J Cachexia Sarcopenia Muscle. 2022 Oct;13(5):2537-2550. doi: 10.1002/jcsm.13050. Epub 2022 Aug 4.
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History
Started
Jul 2023
Main results due
Nov 2023
Finished
Dec 2023