Multimodal Exercise Training to Reduce Frailty in People With Multiple
Multimodal Exercise Training to Reduce Frailty in People With Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- Multimodal Exercise Group
- Waitlist
What it measured
Main measures
Primary Outcome
6 weeks
Physical function
Who could take part
MS (type not specified) · 40 to 65
Show the full criteria
Inclusion criteria
* Subjects must be aged 40-65 years old to be enrolled in this study. * Subjects must meet 3 of 5 frailty criteria (weight loss; exhaustion; weakness; slowness; inactivity) to be considered. * Subjects must have a confirmed diagnosis of MS by the treating neurologist * be free from MS relapses in the last 30 days * have an Expanded Disability Status Scale (EDSS) score ≤ 6.0 * be fluent in spoken and written English.
Exclusion criteria
* unable to walk unassisted for at least ten meters * are diagnosed with other clinically important neurological conditions (such as Parkinson's Disease, epilepsy, etc.) * exhibit severe cognitive impairment (as determined by a Mini-Cog score \<3) * are diagnosed with active psychiatric problems. * unstable cardiovascular conditions (e.g., malignant arrhythmias, critical mitral stenosis, clinically severe left ventricular outflow obstruction, critical proximal coronary artery stenosis) * arthritis of the lower limbs * acute lower back or lower limbs pain * rheumatic and/or severe orthopedic problems that may interfere with resistance training.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Study Significance: This proposed investigation is designed to examine the feasibility of an exercise-based intervention to reduce frailty in people living with MS. The proposed research will be the first to establish the feasibility of targeting frailty in pwMS and will begin to examine the dynamic nature of frailty in MS. These advances will pave the way for planned prospective studies toward effective targets for diagnostics, and rehabilitation of frailty in MS.
Papers
Results
Reducing frailty in frail people with multiple sclerosis: Feasibility of a 6-week multimodal exercise training program.PLoS One · 2026
Results
Zanotto T, Kumar DP, Tabatabaei A, Lynch SG, He J, Herda TJ, Devos H, Thiyagarajan R, Chaves L, Seldeen K, Troen BR, Sosnoff JJ. Multimodal exercise training to reduce frailty in people with multiple sclerosis: study protocol for a pilot randomized controlled trial. Pilot Feasibility Stud. 2024 Apr 22;10(1):65. doi: 10.1186/s40814-024-01496-2.
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History
Started
Nov 2023
Main results due
Feb 2025
Finished
Feb 2025