Action Observation Training With 3D Virtual Reality in Patients With M
Investigation of the Effect of Action Observation Training With 3D Virtual Reality on Upper Extremity Functions in Patients With Multiple Sclerosis With Attacks
We could not find results for this trial
What it found
We found no results in the registry or in papers.
This trial finished 21 months ago. We found no results in the registry or in any paper that cites it.
What was tested
Treatment tested
- Action observation training
Placebo
- sham action observation training
What it measured
Main measures
Box and Block Test
baseline and 6th week
Arm and hand functionnine hole peg test
baseline and 6th week
Arm and hand functionhand dynamometer
baseline and 6th week
Arm and hand functionPhysical function
Other measures (4)
Fatigue severity scale
baseline and 6th week
FatiguePaced Auditory Serial Addition Test
baseline and 6th week
Thinking and memoryThe Arm Function in Multiple Sclerosis Questionnaire
baseline and 6th week
Arm and hand functionMultiple Sclerosis Quality of Life-54
baseline and 6th week
Quality of life (reported by participants)
Who could take part
MS (type not specified) · 18 to 65
Show the full criteria
Inclusion criteria
* \< 2 years MS diagnosis according to McDonald criteria * between 3.5 and 6 the EDSS * Nine Hole Peg Test > 30s for at least one upper extremity * no change in medication in the last 6 months * having MS disease with ongoing attacks * >2 Modified Ashworth Scale in the upper extremities * MOCA>25
Exclusion criteria
* diagnosed with neurological (except MS), cardiopulmonary, metabolic or musculoskeletal disease that would prevent treatment and evaluation * receiving botulinum toxin treatment in the last 6 months * visual impairment uncorrected by optical devices * inability to adapt to treatment based on 3D immersive virtual reality (e.g. with cognitive impairment, communication problems, psychological problems or vestibular system problems)
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Multiple sclerosis is a chronic, autoimmune and inflammatory disease of the Central Nervous System characterized by neuronal demyelination and axonal degeneration. Upper extremity problems are present in MS patients from an early stage, affecting the performance of the individual and leading to a decrease in activity of daily living ability in proportion to the extent of the problem. Action Observation Training is currently being examined as one of the methods used for the improvement of motor disorders and has been shown in the literature to be effective on different functions in neurological diseases. The aim of this study was to investigate the effects of action observation training with 3D virtual reality on upper extremity functions, fatigue, cognitive functions, activities of daily living and quality of life in MS patients. Hypothesis 1: Action observation training with 3D virtual reality has an effect on upper extremity functions in MS patients. Hypothesis 2: Action observation training with 3D virtual reality has an effect on cognitive function in MS patients. Hypothesis 3: Action observation training with 3D virtual reality has an effect on fatigue in MS patients. Hypothesis 4: Action observation training with 3D virtual reality has an effect on activities of daily living in MS patients. Hypothesis 5: Action observation training with 3D virtual reality has an effect on quality of life in MS patients.
Papers
Background
Bunday KL, Lemon RN, Kilner JM, Davare M, Orban GA. Grasp-specific motor resonance is influenced by the visibility of the observed actor. Cortex. 2016 Nov;84:43-54. doi: 10.1016/j.cortex.2016.09.002. Epub 2016 Sep 11.Background
Choi JW, Kim BH, Huh S, Jo S. Observing Actions Through Immersive Virtual Reality Enhances Motor Imagery Training. IEEE Trans Neural Syst Rehabil Eng. 2020 Jul;28(7):1614-1622. doi: 10.1109/TNSRE.2020.2998123.Background
Rocca MA, Meani A, Fumagalli S, Pagani E, Gatti R, Martinelli-Boneschi F, Esposito F, Preziosa P, Cordani C, Comi G, Filippi M. Functional and structural plasticity following action observation training in multiple sclerosis. Mult Scler. 2019 Oct;25(11):1472-1487. doi: 10.1177/1352458518792771. Epub 2018 Aug 7.Background
Sollfrank T, Hart D, Goodsell R, Foster J, Tan T. 3D visualization of movements can amplify motor cortex activation during subsequent motor imagery. Front Hum Neurosci. 2015 Aug 20;9:463. doi: 10.3389/fnhum.2015.00463. eCollection 2015.Background
Yoshimura M, Kurumadani H, Hirata J, Osaka H, Senoo K, Date S, Ueda A, Ishii Y, Kinoshita S, Hanayama K, Sunagawa T. Virtual reality-based action observation facilitates the acquisition of body-powered prosthetic control skills. J Neuroeng Rehabil. 2020 Aug 20;17(1):113. doi: 10.1186/s12984-020-00743-w.Background
Yu JA, Park J. The effect of first-person perspective action observation training on upper extremity function and activity of daily living of chronic stroke patients. Brain Behav. 2022 May;12(5):e2565. doi: 10.1002/brb3.2565. Epub 2022 Apr 10.
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History
Started
Nov 2023
Main results due
Feb 2025
Finished
Mar 2025