Effect of TTNS and PNS on Neurogenic Overactive Bladder Symptoms in Fe

Effect of Transcutaneous Posterior Tibial Nerve Stimulation and Parasacral Transcutaneous Electrical Stimulation on Neurogenic Overactive Bladder Symptoms in Female Patients With Multiple Sclerosis.

CompletedNot a drug-phase studyMS (type not specified)NCT06143397

We could not find results for this trial

What it found

No results found

We found no results in the registry or in papers.

This trial finished 12 months ago. We found no results in the registry or in any paper that cites it.

What was tested

Treatment tested

  • TTNS (Transcutaneous tibial nerve stimulation)
  • PNS (Parasacral nerve stimulation)

Placebo

  • Sham stimulation

Given to everyone in the trial

  • Behavioral treatment

What it measured

Main measures

  • Uroflowmetry

    Baseline

    Bladder, bowel and sexual function

  • Uroflowmetry

    After the 6-week intervention

    Bladder, bowel and sexual function

  • Post voiding residue (PVR)

    Baseline

    Bladder, bowel and sexual function

  • Post voiding residue (PVR)

    After the 6-week intervention

    Bladder, bowel and sexual function

Other measures (10)

  • Overactive bladder form (OAB-v8)

    Baseline

    Bladder, bowel and sexual function

  • Three-day bladder diary (BD)

    Baseline

    Bladder, bowel and sexual function

  • King's Quality of Life Questionnaire (KHQ)

    Baseline

    Bladder, bowel and sexual functionQuality of life (reported by participants)

  • Incontinence Severity Index (ISI)

    Baseline

    Bladder, bowel and sexual function

  • Neurogenic Bladder Symptom Score (NBSS)

    Baseline

    Bladder, bowel and sexual function

  • Overactive bladder form (OAB-v8)

    After the 6-week intervention

    Bladder, bowel and sexual function

  • Three-day bladder diary (BD)

    After the 6-week intervention

    Bladder, bowel and sexual function

  • King's Quality of Life Questionnaire (KHQ)

    After the 6-week intervention

    Bladder, bowel and sexual functionQuality of life (reported by participants)

  • Incontinence Severity Index (ISI)

    After the 6-week intervention

    Bladder, bowel and sexual function

  • Neurogenic Bladder Symptom Score (NBSS)

    After the 6-week intervention

    Bladder, bowel and sexual function

Who could take part

MS (type not specified) · 18 to 65

Show the full criteria

Inclusion criteria

* Having symptoms related to overactive bladder (OAB-v8 score ⩾8), * Over 18 years of age * No relapse for at least 1 month * All types of MS, including those with relapses * Female MS patients with an Expanded Disability Status Scale (EDSS) score below 7.0 * Agreeing to participate in the research

Exclusion criteria

* Patients with urinary tract infections * Patients diagnosed with diabetes mellitus * Patients using diuretic drugs or patients with a clean intermittent catheter * Patients with a history of different urological diseases * Patients with heart or brain pacemaker users, those with epilepsy, and patients with language and cognitive limitations * Patients who are pregnant or in the postpartum period * Lack of activity performance for 2 weeks (regardless of which group)

As registered. Criteria can change, so ask the trial team or your neurologist.

About this trial

In the sponsor's words

This study aims to evaluate the use of transcutaneous tibial nerve stimulation (TTNS) and parasacral nerve stimulation (PSS) methods in the treatment of overactive bladder (OAB) symptoms in patients with Multiple Sclerosis (MS), including urination frequency, urgency, urinary incontinence, post-void residue, maximum micturition rate. To investigate the effect on parameters such as voiding volume and quality of life and to compare the final results between groups.

Papers

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History

    1. Started

      Nov 2023

    2. Main results due

      Oct 2025

    3. Finished

      Oct 2025

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