A Novel Combinatory Approach to Maximize Functional Recovery of Learni

A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis

RecruitingNot a drug-phase studyMS (type not specified)NCT06197685

What it found

Still running

No result yet.

What was tested

Treatment tested

  • The Kessler Foundation modified Story Memory Technique® (KF-mSMT®)
  • Aerobic Exercise Training (AET) plus Virtual Reality (IDEAL)
  • Stretching and Toning (S/T)

What it measured

Main measures

  • Change in objective new learning and memory (NLM).

    Weeks 1 and 2 (pre-intervention) and Weeks 15 and 16 (post-intervention)

    Thinking and memory

  • Change in everyday memory

    Weeks 1 and 2 (pre-intervention) and Weeks 15 and 16 (post-intervention)

    Thinking and memory

Other measures (2)

  • Change in hippocampal volume

    Weeks 1 and 2 (pre-intervention) and Weeks 15 and 16 (post-intervention)

    MRI lesions

  • Change in hippocampal function

    Weeks 1 and 2 (pre-intervention) and Weeks 15 and 16 (post-intervention)

    Nerve conduction tests

Who could take part

MS (type not specified) · 18 to 70

Show the full criteria

Inclusion criteria

* Be within the ages of 18 and 70 years of age * Speak English as their primary language * Confirmed MS diagnosis by a neurologist * Be relapse and steroid-free for at least 30 days * Mild-to-moderate self-reported mobility disability, based on the Patient Determined Disease Steps scale (PDDS) * Currently physically inactive, based on the Godin Leisure Time Exercise Questionnaire (GLTEQ) * Right handedness

Exclusion criteria

* History of neurological disorders besides MS or history of uncontrolled psychiatric disorders (ex: major depression) * Have contraindications to exercise, based on the Physical Activity Readiness Questionnaire (PAR-Q) * Currently use medications that may impact cognition (ex: steroids, benzodiazepines) * Currently pregnant * Contraindication for MRI (metal or electronic devices in the body that are not considered MRI safe) * Severe cognitive impairment as measured by the Modified Telephone Interview of Cognitive Status (TICS-M)

As registered. Criteria can change, so ask the trial team or your neurologist.

Contact details on the registry

About this trial

In the sponsor's words

The goal of this novel study is to compare the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory (NLM) in persons with multiple sclerosis (pwMS) and mobility disability.

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History

    1. Started

      Feb 2024

    2. Main results due

      Sept 2027

    3. Finished

      Sept 2027

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