Cerebellar RTMS in Patients with Multiple Sclerosis
Effect of Cerebellar Repetitive Transcranial Magnetic Stimulation on Coordination in Patients with Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- High frequency repetitive transcranial magnetic stimulation
Placebo
- Sham repetitive transcranial magnetic stimulation
What it measured
Main measures
Biodex balance system
2 weeks after end of treatment
Walking and mobility
Other measures (3)
Berg balance scale
2 weeks after end of treatment
Walking and mobilityNine-Hole Peg Test (9-HPT)
2 weeks after end of treatment
Arm and hand functionFour square step test (FSST)
2 weeks after end of treatment
Walking and mobility
Who could take part
Progressive MS · 20 to 45
Show the full criteria
Inclusion criteria
* Clinically definite MS (relapsing, remitting and secondary progressive) patients * Patients who are medically stable and Free from relapses three months before * Ambulant patients without an assistive device and score less than 5 on the Kurtzke Expanded Disability Status Scale (EDSS) * Patients receiving their disease modifying drugs but no medication changing during the previous three months. * Patients who had MRI evidence of lesions in the cerebellum or in the cerebellar pedunculi. * Right handed patients. * Severity of ataxia range from 4 to 10 according to scale of assessment and rating ataxia (SARA). * Did not apply cerebellar transcranial magnetic stimulation before.
Exclusion criteria
* Any other neurological deficits or orthopedics abnormalities. * Ataxic manifestations for other cause rather than Multiple Sclerosis. * Other neurological manifestations (e.g. spasticity, visual loss) * Secondary musculoskeletal complication such as contractures or deformities. Cardiovascular, pulmonary, hepatic, renal, hemopoietic and thyroid diseases. * Pregnant women. * Addicted individuals. * Previous surgeries in the brain. * Any magnetic or metallic devices implanted (like cochlear implants) . * Psychotic deficits or history of epileptic seizures.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
To determine the efficacy of high frequency cerebellar repetitive transcranial magnetic stimulation on coordination in patients with multiple sclerosis.
Papers
Results
Cerebellar repetitive transcranial magnetic stimulation combined with physiotherapy for balance in people with multiple sclerosis: A randomized controlled trial with six-week follow-up.Mult Scler Relat Disord · 2025
Background
Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, Filipovic SR, Grefkes C, Hasan A, Hummel FC, Jaaskelainen SK, Langguth B, Leocani L, Londero A, Nardone R, Nguyen JP, Nyffeler T, Oliveira-Maia AJ, Oliviero A, Padberg F, Palm U, Paulus W, Poulet E, Quartarone A, Rachid F, Rektorova I, Rossi S, Sahlsten H, Schecklmann M, Szekely D, Ziemann U. Evidence-based guidelines on thBackground
Aloizou AM, Pateraki G, Anargyros K, Siokas V, Bakirtzis C, Liampas I, Nousia A, Nasios G, Sgantzos M, Peristeri E, Dardiotis E. Transcranial magnetic stimulation (TMS) and repetitive TMS in multiple sclerosis. Rev Neurosci. 2021 Feb 25;32(7):723-736. doi: 10.1515/revneuro-2020-0140. Print 2021 Nov 25.Background
Somaa FA, de Graaf TA, Sack AT. Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases. Front Neurol. 2022 May 20;13:793253. doi: 10.3389/fneur.2022.793253. eCollection 2022.
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History
Started
Feb 2024
Main results due
Jul 2024
Finished
Aug 2024