Intermittent Hypoxia in Persons With Multiple Sclerosis
Intermittent Hypoxia Initiated Motor Plasticity in Individuals With Multiple Sclerosis
What it found
No result yet.
What was tested
Treatment tested
- Acute Intermittent Hypoxia
Placebo
- Sham-Acute Intermittent Hypoxia
What it measured
Main measures
Ankle Plantarflexion Strength
Before and following each 5-day intervention block
Physical function
Other measures (1)
Task fMRI
Before and following each 5-day intervention block
Nerve conduction tests
Who could take part
Relapsing and progressive · 18 to 75
Show the full criteria
Inclusion criteria
* Diagnoses of relapsing form of MS (including relapsing-remitting MS and secondary-progressive MS) * Expanded Disability Status Scale (EDSS) score of at least 3 and no more than 6.5 * Motor Functional System Scale (FSS) between 2-4 * Relapse free for at least 1 year * Age ≥ 18 years and ≤ 75 years * Safe to be scanned based on MRI questionnaire * Participants using dalfampridine will be eligible if taking the same daily dose for at least 2 months prior to screening
Exclusion criteria
* Active contrast-enhancing MS lesions, or diffusion positive lesions suggestive of acute cerebrovascular disease on baseline MRI scan * Uncontrolled hypertension (Systolic between 85 and 140, diastolic between 90 and 55) * History of epilepsy * Chronic obstructive pulmonary disease * Uncontrolled Sleep apnea * Pregnancy
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
This study aims to understand the mechanisms of a novel intervention involving breathing short durations of low levels of oxygen for persons with multiple sclerosis (MS). This intervention with low levels of oxygen is called Acute Intermittent Hypoxia (AIH), the levels of oxygen experienced are similar to breathing the air on a tall mountain, for less than 1 minute at a time. Previous studies have shown that AIH is a safe and effective way to increase strength in persons with MS. Here the investigators aim to look at brain activation and ankle strength before and after AIH to gain a better understanding of how the AIH may improve strength in those persons with MS.
Papers
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History
Started
Apr 2024
Main results due
Nov 2025
Finished
Jan 2027