COld Exposure With Controlled BReathing And Meditation in Patients Wit
COld Exposure With Controlled BReathing And Meditation in Patients With Multiple Sclerosis (COBRAMS)
What it found
We found no results in the registry or in papers.
What was tested
Treatment tested
- Wim Hoff method
What it measured
Main measures
concentration of pro-inflammatory cytokines
12 weeks
Immune responseconcentration of markers of oxidative stress
12 weeks
concentration of NfL
12 weeks
Blood or spinal fluid markersconcentration of GFAP
12 weeks
Blood or spinal fluid markersconcentration of ecDNA
12 weeks
Other measures (7)
Expanded Disability Status Scale
12 weeks
Disability progressionTimed 25-Foot Walk
12 weeks
Disability progressionWalking and mobilityNine-Hole Peg Test
12 weeks
Arm and hand functionSymbol Digit Modalities Test
12 weeks
Thinking and memoryFatigue Scale for Motor and Cognitive Functions
12 weeks
Thinking and memoryFatigueGeneral Anxiety Disorder-7
12 weeks
Mood and sleepPatient Health Questionnaire-9
12 weeks
Mood and sleep
Who could take part
Relapsing MS · 18 to 55 · EDSS 1.0 to 5.5
Show the full criteria
Inclusion criteria
* RRMS diagnosed according to the official 2020 McDonald's criteria, * age 18-55 years, * MS duration up to 10 years, * EDSS 1.0-5.5, * willingness to participate
Exclusion criteria
* relapse or corticosteroid treatment within 3 months prior to study enrollment * severe/unstable comorbidity
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
The goal of this interventional study is to test the effect of the anti-inflammatory and neuroprotective effects of this supplementary training program that includes breathing exercises, cold exposure, and meditation in patients diagnosed with multiple sclerosis. Researchers will compare the effect to control groups of MS patients without intervention.
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History
Started
Sept 2022
Main results due
Dec 2025
Finished
Dec 2025