Resistance Training and Corticospinal Excitability in Multiple Scleros
Effects of Supervised Progressive Resistance Training on Central Nervous System Functioning (Corticospinal Excitability) and Walking Capacity in Persons With Multiple Sclerosis
What it found
No result yet.
What was tested
Treatment tested
- Progressive resistance training
What it measured
Main measures
MEP/Mmax ratio
Change from Baseline to 10 weeks
Nerve conduction tests
Other measures (31)
Muscle strength
Change from Baseline to 10 weeks
Physical functionVoluntary activation I
Change from Baseline to 10 weeks
Voluntary activation II
Change from Baseline to 10 weeks
Force Steadiness
Change from Baseline to 10 weeks
Rate of Force Developement
Change from Baseline to 10 weeks
Ultrasound
Change from Baseline to 10 weeks
Resting Motor Threshold (rMT)
Change from Baseline to 10 weeks
Myelin repairNerve conduction testsActive Motor Threshold (aMT)
Change from Baseline to 10 weeks
Myelin repairNerve conduction testsMEP latency (resting)
Change from Baseline to 10 weeks
Myelin repairNerve conduction testsMEP latency (active)
Change from Baseline to 10 weeks
Myelin repairNerve conduction tests
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* Age ≥ 18 years * MS diagnosis according to the McDonald diagnostic criteria * Shows impairments in walking capacity * Ability to self transport to test and exercise
Exclusion criteria
* Pregnancy * Neurological or other comorbidities that affects the nervous system * Relapse within the past 2 months * Pacemaker or metallic implants * Hypertension (medically unregulated) * Participation in structured RT over the past 3 months (≥ 2 sessions/week).
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
The goal of the present study is to investigate effects of progressive resistance training on central nervous system functioning (corticospinal excitability (CSE)) and walking capacity in persons with multiple sclerosis (pwMS). A total of 54 pwMS will be enrolled and randomized into 1 of 3 groups: high dose resistant training (RT), low dose RT, and waitlist control.
Papers
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History
Started
May 2024
Main results due
Dec 2025
Finished
May 2026