Effects of Acute Intermittent Hypoxia on Neuroplasticity in MS
Investigating the Effects of Acute Intermittent Hypoxia on Neuroplasticity in Persons With Multiple Sclerosis
What it found
No result yet.
What was tested
Treatment tested
- Acute Intermittent Hypoxia
Placebo
- Sham Acute Intermittent Hypoxia
What it measured
Main measures
Motor Evoked Potentials (MEPs) in First Dorsal Interosseous (FDI)
Immediately before, immediately after, and 60 minutes after the intervention.
Myelin repairNerve conduction testsChanges in Spinal Reflex Threshold
Immediately before the intervention and immediately after the intervention.
Threshold For Detecting Passive Joint Movement
Immediately before the intervention and immediately after the intervention.
Accuracy of Direction Estimation of Passive Joint Movement
Immediately before the intervention and immediately after the intervention.
Other measures (9)
Grip Strength
Immediately before the intervention and immediately after the intervention.
Arm and hand functionPhysical functionPinch Strength
Immediately before the intervention and immediately after the intervention.
Physical functionIndex Finger Abduction Force
Immediately before the intervention and immediately after the intervention.
Nine-Hole Peg Test
Immediately before the intervention and immediately after the intervention.
Arm and hand functionSymbol Digit Modalities Test
Immediately before the intervention and immediately after the intervention.
Thinking and memoryBox and Block Test
Immediately before the intervention and immediately after the intervention.
Arm and hand functionModified Ashworth Scale
Immediately before the intervention and immediately after the intervention.
SpasticityIpsilateral Joint Position Matching Task
Immediately before the intervention and immediately after the intervention.
Visual Analog Pain Scale
Immediately before the intervention and immediately after the intervention.
Pain
Who could take part
Relapsing and progressive · 18 to 75
Show the full criteria
Inclusion criteria
* Diagnosis of relapsing-remitting MS according to the McDonald criteria, over 5 years ago * Relapse free for at least 6 months * Expanded Disability Status Scale (EDSS) ≤7 * Index finger abduction strength \<5 according to Medical Research Council Scale, or 9-Hole Peg Test score >20 seconds in at least one hand * Stable disease modifying therapies for at least 6 months * Individuals taking dalfampridine will be eligible if taking the same daily dose for at least 2 months prior to screening
Exclusion criteria
* Another diagnosis (e.g., peripheral neuropathies or orthopedic) affecting upper limb function * Mini-Mental State Examination (MMSE) score \<24 * Modified Ashworth Scale score >3 on elbow joint * Uncontrolled hypertension or hypotension (outside 140/90 and 85/55 mmHg) * History of epilepsy, chronic obstructive pulmonary disease, or sleep apnea * Unstable medical conditions, ongoing upper limb therapy, or musculoskeletal pain * Pregnancy as confirmed by urine test
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
This study seeks to explore changes in the neural pathways and arm function following a breathing intervention in the multiple sclerosis (MS) population. The breathing intervention, known as Acute Intermittent Hypoxia (AIH), involves breathing brief bouts of low levels of oxygen. Research has found AIH to be a safe and effective intervention resulting in increased ankle strength in people with MS. Here, the study examines arm and hand function before and after AIH. In order to better understand the brain and spinal cord response to AIH, the investigators will measure muscle response, and signals sent from the brain to the arm muscles before and after AIH.
Papers
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History
Started
Feb 2025
Main results due
Jul 2026
Finished
Jul 2027