Electrical Brain Stimulation for Treatment of Secondary Symptoms in Mu
Electrical Brain Stimulation for Improving Mental Health and Cognitive Functioning in Patients With Multiple Sclerosis
What it found
A paper reports the results; we have not read it yet. See Papers below.
What was tested
Treatment tested
- transcranial direct current stimulation combined with cognitive training
Compared with
- transcranial direct current stimulation
Placebo
- transcranial direct current stimulation
What it measured
Main measures
Multiple Sclerosis Impact Scale (MSIS-29)
up to 1 day after the intervention
Quality of life (reported by participants)and Depression Anxiety Stress Scale-21 (DASS-21)
up to 1 day after the intervention
Mood and sleepMini sleep questionnaire (MSQ)
up to 1 day after the intervention
Mood and sleep
Other measures (2)
psychomotor speed task
up to 1 day after the intervention
attention / vigilance task
up to 1 day after the intervention
Thinking and memory
Who could take part
MS (type not specified) · 18 to 60
Show the full criteria
Inclusion criteria
1. diagnosis of MS according to the diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria (Polman et al., 2011), certified by a professional neurologist 2. being 25-55 years old 3. providing written informed consent 4. If female, a negative urine pregnancy test 5. stable medication regime especially the classical neuroleptics and all CNS-activating medications, if taken, 4-6 weeks before the experiment and during the experiment 6. right handed
Exclusion criteria
1. smoker 2. pregnancy 3. alcohol or substance dependence 4. history of seizure 5. history of other neurological disorders than MS 6. history of head injury 7. presence of ferromagnetic objects in the body that are contraindicated for brain stimulation of the head (pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips, metallic prostheses, permanent eyeliner, implanted delivery pump, or shrapnel fragments) or fear of enclosed spaces.
As registered. Criteria can change, so ask the trial team or your neurologist.
About this trial
In the sponsor's words
Multiple Sclerosis (MS) is an autoimmune disease associated with physical disability, psychological impairment, and cognitive dysfunction. As a result, the disease burden is high, and treatment options are limited. In this randomized, double-blind study, the investigators planned to use repeated electrical stimulation and assess mental health-related variables (e.g., quality of life, sleep, psychological distress) and cognitive dysfunction in patients with MS.
Papers
Loading reviews and guidelines…
History
Started
Feb 2023
Main results due
Dec 2023
Finished
Jan 2024