Exercise Rehabilitation Program in MS Who Use Wheelchairs as a Primary
Randomized Pilot Study Evaluating the Effect of a 6-Month Exercise Rehabilitation Program on Physical and Cognitive Function in Persons With MS Who Use Wheelchairs as a Primary Mobility Device
What it found
No result yet.
What was tested
Treatment tested
- Exercise rehabilitation program
What it measured
Main measures
Physical Function
Changes in physical function scores from Baseline (pre-intervention), after 3 months (mid-intervention), and after 6 months (post-intervention)
Walking Speed
Changes in physical function scores from Baseline (pre-intervention), after 3 months (mid-intervention), and after 6 months (post-intervention)
Disability progressionWalking and mobilityLower-Extremity Function
Changes in physical function scores from Baseline (pre-intervention), after 3 months (mid-intervention), and after 6 months (post-intervention)
Walking Endurance
Changes in physical function scores from Baseline (pre-intervention), after 3 months (mid-intervention), and after 6 months (post-intervention)
Walking and mobility
Other measures (8)
Cognitive Function
Changes in physical function scores from Baseline (pre-intervention), after 3 months (mid-intervention), and after 6 months (post-intervention)
Thinking and memoryFatigue Severity
Changes in physical function scores from Baseline (pre-intervention), after 3 months (mid-intervention), and after 6 months (post-intervention)
FatigueFatigue Impact
Changes in physical function scores from Baseline (pre-intervention), after 3 months (mid-intervention), and after 6 months (post-intervention)
FatigueDepressive Symptoms
Changes in physical function scores from Baseline (pre-intervention), after 3 months (mid-intervention), and after 6 months (post-intervention)
Mood and sleepAnxiety
Changes in physical function scores from Baseline (pre-intervention), after 3 months (mid-intervention), and after 6 months (post-intervention)
Mood and sleepHealth-Related Quality of Life
Changes in physical function scores from Baseline (pre-intervention), after 3 months (mid-intervention), and after 6 months (post-intervention)
Quality of life (reported by participants)Exercise Behavior
Changes in physical function scores from Baseline (pre-intervention), after 3 months (mid-intervention), and after 6 months (post-intervention)
Physical functionUsual Pattern of Mobility in Various Life-Space Levels
Changes in physical function scores from Baseline (pre-intervention), after 3 months (mid-intervention), and after 6 months (post-intervention)
Walking and mobility
Who could take part
MS (type not specified) · 18 and over
Show the full criteria
Inclusion criteria
* diagnosis of MS * age above 18 years * no relapse within last 30 days * use of wheelchair for mobility in the community * ability to walk at least 50 feet (or 65 steps) using an assistive device * low risk for contraindications of physical activity indicated by no more than a single "yes" * response on the Physical Activity Readiness Questionnaire (PAR-Q) * willingness to complete the assessments and undergo randomization
Exclusion criteria
* no diagnosis of MS * less than 18 years of age * not relapse-free within the last 30 days * no use of wheelchair as primary mobility device * no ability to walk for at least 50 feet (or 65 steps) * high risk for contraindications based on more than a single "yes" response on the PAR-Q * not willing to complete the testing procedures and undergo randomization
As registered. Criteria can change, so ask the trial team or your neurologist.
Contact details on the registryAbout this trial
In the sponsor's words
Approximately 50% of people with multiple sclerosis (MS) use a wheelchair within 30 years of the initial diagnosis. Wheelchair use in MS is often associated with fatigue as a consequence of muscle weakness. Indeed, fatigue, a prevalent consequence of MS, often becomes debilitating and exhausts energetic resources when carrying-out tasks of daily life and/or interacting with the community, as these require ambulatory mobility. This experience of excessive fatigue has its roots in muscle weakness and results in reliance on a wheelchair for mobility, and the dependency on a wheelchair may further reduce muscular strength, particularly of the lower extremities. We propose that wheelchair users with MS can increase muscular strength through a personalized exercise rehabilitation, and this in turn will improve ambulatory performance and possibly reduce fatigue. To date, no research has examined the effects of this specific exercise rehabilitation program (GH method) on physical function and other disease-related outcomes in persons with MS who use wheelchairs as a primary mobility device.
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History
Started
Apr 2024
Main results due
Jul 2026
Finished
Jul 2027